miRNA在皮肤紫外线光反应中的作用  

Roles of miRNAs in skin responses to ultraviolet radiation

作　　者：栗丹[1] 吴迪[1] 周炳荣[1] 骆丹[1] 

机构地区：[1]南京医科大学第一附属医院皮肤性病科,南京210029

出　　处：《国际皮肤性病学杂志》2015年第4期243-245,共3页International Journal of Dermatology and Venereology

基　　金：国家自然科学基金（81000700）

摘　　要：日光的紫外线照射是一种常见的环境致癌因素.人类皮肤长期暴露于紫外线照射（特别是长波紫外线和中波紫外线）可引起多种伤害,如,红斑、色素沉着、免疫抑制、光老化和皮肤肿瘤等.为了避免这些损伤维持基因完整性,细胞自身具有多种保护机制,包括DNA修复、细胞周期阻滞和诱发凋亡等.研究表明,miRNA在紫外线照射引起的各种细胞反应中发挥了重要作用,与人类一系列的光照后皮肤损伤反应和疾病有关.Solar ultraviolet （UV） radiation is a ubiquitous carcinogenic environmental factor.Long-term exposure of human skin to UV radiation （particularly UVA and UVB） can cause a variety of adverse changes,such as erythema,pigmentation,immunosuppression,photoaging,skin neoplasms,and so on.To avoid these adverse changes and maintain genetic integrity,cells themselves have various protective mechanisms,including DNA repair,cell cycle block and apoptosis induction.Studies have indicated that miRNAs play important roles in various cellular reactions induced by UV radiation,and are associated with a series of adverse cutaneous reactions and dermatoses following UV radiation.

关 键 词：微RNAS 紫外线 光 创伤和损伤 皮肤肿瘤 

分 类 号：R758.1[医药卫生—皮肤病学与性病学]