Tosight喉镜用于新生儿气管插管时七氟醚吸入肺泡气浓度  

A study on minimum alveolar concentration EI_(50)and EI_(95)sevoflurane during intubation with Tosight video larygoscope in neonates

作　　者：陈丽丽[1] 张建敏[1] 郑铁华[1] 

机构地区：[1]首都医科大学附属北京儿童医院麻醉科,北京100045

出　　处：《首都医科大学学报》2015年第3期469-472,共4页Journal of Capital Medical University

摘　　要：目的测定新生儿Tosight喉镜气管插管时七氟醚吸入的半数肺泡气浓度（minimum alveolar concentrations effective inhaled concentrations in 50%,MAC EI50）和95%有效肺泡气浓度（minimum alveolar concentrations effective inhaled concentrations in95%,MAC EI50）。方法选择22例美国麻醉医师协会（American Society of Anesthesiologists,ASA）1或Ⅱ级择期全身麻醉手术的新生儿,吸入七氟醚麻醉,初次浓度设置为3.3%,相邻浓度比为1.1,七氟醚的浓度按改良序贯法增加或减少一级,待七氟醚的浓度达血一脑平衡10 min后行气管插管。用概率单位回归法计算出新生儿Tosight喉镜气管插管时七氟醚吸入诱导的肺泡气浓度MAC EI50和EI95及相应的95%可信区间（confidence interval,95%CI）。结果全凭七氟醚吸入诱导Tosight喉镜气管插管时患儿肺泡气浓度的MAC EI50为3.65%,95%CI为3.28%4.04%;MAC EI95为4.24%,95%CI为3.93%7.14%。结论 Tosight喉镜用于新生儿气管插管时的肺泡气浓度的MAC EI50和EI95分别为3.65%和4.24%。Objective To measure the minimum alveolar concentration（MAC EI50 and EI95） of sevoflurane during intubation with Tosight video larygoscope in neonates.Methods Twenty-two ASA I or E infants under operations in general anesthesia were induced by sevoflurane.Initial concentration is set to 3.3%,the adjacent concentration ratio is 1.1.The concentration of sevoflurane was determined via the modified Dixon’s up-and-down method（a level as a step size）.After equilibrium between blood and brain concentration of sevoflurane,the trachea was intubated.Probit analysis was used for calculating MAC EI50,EI95 and 95%confidence interval（95%CI）.Results The MAC EI50 of sevoflurace was 3.65%（95%CI：3.28%-4.04%） and EI95 of sevoflurace was 4.24%（95%CI：3.93%-7.14%）.Conclusion The MAC EI50 and EI95 of sevoflurane during Tosight video laryngoscope intubation in neonates were 3.65%and 4.24%.

关 键 词：Tosight喉镜 七氟醚 新生儿 改良序贯法 

分 类 号：R246.2[医药卫生—针灸推拿学]