中药通腑颗粒治疗脓毒症肠衰竭的疗效及机制探讨(英文)  

Exploring therapeutic mechanisms of traditional Chinese medicine Tongfu granule in preventing sepsis-induced intestinal dysmotility

作　　者：苏艳丽[1] 王红[1] 张淑文[1] 王宝恩[1] 任爱民[1] 苗斌[1] 王超[1] 

机构地区：[1]首都医科大学附属北京友谊医院感染内科,北京100050

出　　处：《首都医科大学学报》2015年第3期497-500,共4页Journal of Capital Medical University

基　　金：国家自然科学基金(81173411);北京市科学技术委员会重大科技项目(H020920050130);北京市中医局中西医结合项目(51510)~~

摘　　要：胃肠功能衰竭是脓毒症患者常见合并症,流行病学调查研究显示我国重度脓毒症患者中胃肠功能不全的发病率可高达78.8%,是引起脓毒症患者死亡的重要原因。经多年临床研究证实,中药通腑颗粒（专利号：200710122532.2）可提高临床多脏器功能不全患者的肠动力、降低血浆二胺氧化酶（diamine oxidase,DAO）活性、降低D-乳酸水平,提高APACHEⅡ评分为8~20分的患者的28天生存率。动物实验研究证实,通腑颗粒可减轻肠道炎性反应,降低促炎因子水平,改善肠道微生态环境,减少肠道淋巴细胞凋亡,改善肠道免疫屏障功能。厚朴酚是通腑颗粒中的有效成分,可通过调节Cajal细胞Kit/SCF信号通路,改善脓毒症患者的肠动力。Intestinal dysmotility is the frequent complications in patients with sepsis.Our epidemiological investigation from 37 hospitals in China showed that the incidence of gastrointestinal dysfunction in the severe sepsis patients were 78.8%.During treatment of gastrointestinal dysfunction in patients with multiple organ dysfunction syndrome（MODS）,Tongfu granule（Chinese patents200710122532.2） treatment was found to enhance the intestinal motility,lower the activity of plasma diamine oxidase（DAO） and level of D-lactic acid,and lower the mortality in 28 days in patients whose APACHE Ⅱ score was between 8-20.Animal experimental studies showed that in LPS-induced endotoxemia,Tongfu granules were found to protect the intestinal immune function due to reducing the injury of small intestinal mucosa and immune cells and decreasing intestinal lymphocyte apoptosis.In addition,Tongfu granules could protect the intestinal microflora barrier function.Magnolol（5,5-diallyl-2,2-dihydroxybiphenyl）is one of the major active compounds of Tongfu granules.Magnolol treatment was found to prevent by regulating SCF/c-kit and NO signaling to maintain functional interstitial cells of Cajal（ICCs）.

关 键 词：通腑颗粒 厚朴酚 脓毒症 肠衰竭 CAJAL细胞 免疫 

分 类 号：R285[医药卫生—中药学]