机械通气患者右美托咪定和咪达唑仑镇静效果的比较  

Difference of Exmedetomidine and Midazolam in Mechanical Ventilation Patients

作　　者：曲茂兴[1] 于健[1] 

机构地区：[1]大连医科大学附属第二医院重症医学科(中心ICU),辽宁大连116027

出　　处：《医学与哲学（B）》2015年第6期27-29,共3页Medicine & Philosophy(B)

摘　　要：比较机械通气的患者,应用右美托咪定和咪达唑仑进行镇静治疗的效果。机械通气的患者分为右美托咪定组和咪达唑仑组,回顾性分析治疗前后的临床资料。右美托咪定组和咪达唑仑组机械通气时间的比较,差异无统计学意义(P>0.05)。两组患者谵妄的发生率、阿片类药物的使用率、药物停止至唤醒所需要的时间、循环系统不良反应的例数比较,差异有统计学意义(P<0.05)。右美托咪定用于机械通气患者的镇静治疗,易于从镇静状态中恢复,降低谵妄的发生率,但可引起血压、心率的下降。应用咪达唑仑的患者可以减少阿片类药物的使用,循环系统不良反应的发生率较右美托咪定低。右美托咪定和咪达唑仑可作为ICU的镇静药物。To evaluate the difference between exmedetomidine and midazolam of among mechanical ventilation patients . Patients were divided into exmedetomidine group and midazolam group ,and retrospective clinical data was analyzed .The incidence of delirium and arousal time were statistically significant in group exmedetomidine .And the use of opioid rate and the adverse reaction of the circulatory system were statistically significant in group midazolam . But the mechanical ventilation time were not statistically significant （P〉0 .05） .In exmedetomidine group ,patients were prone to recovery from sedation ,and delirium did not easily occur .In midazolam group ,patients needed a few opioids ,and the adverse reaction of the circulatory system happened less .Exmedetomidine and midazolam are effective sedative drugs .

关 键 词：右美托咪定 咪达唑仑 机械通气 

分 类 号：R459.9[医药卫生—治疗学] R595.4[医药卫生—临床医学]