探讨游离脂肪酸和糖化血红蛋白与子痫前期糖脂代谢异常的相关性  

Exploration on the relationahip between glycosylated hemoglobin(HbA1c) and preeclampsia abnormal glucose & lipid metabolism

作　　者：陈柳青[1] 连炬飞[1] 周永贤[1] 赖科峰[1] 林珠[1] 

机构地区：[1]广东省妇幼保健院,广东广州510010

出　　处：《中国优生与遗传杂志》2015年第7期54-56,共3页Chinese Journal of Birth Health & Heredity

摘　　要：目的探讨游离脂肪酸(Free fatty acid,FFA)和糖化血红蛋白(glycosylated hemoglobin,Hb A1c)联合监测与子痫前期(Preeclampsia,PE)糖脂代谢异常的相关性。方法选取99例子痫前期患者(PE组)和93例正常妊娠孕妇(对照组),分别检测FFA、Hb A1c、空腹血糖(Fasting plasma glucose,FPG)、甘油三酯(Triglycerides,TG)、胆固醇(Cholesterol,TCH),并对结果进行分析比较。结果 PE组与对照组比较,重度PE组和轻度PE组相比较,FFA、Hb A1c、FPG、TG、TCH差异均有统计学意义(P<0.05)。PE组FFA与Hb A1c呈正相关(r=0.768),且FFA和Hb A1c浓度与PE病情轻重呈正相关(r=0.668、0.528)。结论高FFA和Hb A1c血症与PE糖脂代谢异常存在密切的关系,联合监测对了解PE糖脂代谢异常及其病情发展、预后判断具有重要的临床指导意义。Objective：Discussion on relationship between monitoring free fatty acid（FFA）and glycosylated hemoglobin（Hb A1c）and preeclampsia abnormal glucose lipid metabolism. Method：99 preelampsia cases are selected in one group（PE group）,while 93 normal cases in control group,dectecting and comparing the result of FFA、Hb A1c、FPG（fasting plasma glucose）、TG（Triglycerides）、TCH（Cholesterol）. Results：Comparison with PE group vs control group and severe PE group vs light PE group,there are significance in FFA、Hb A1c、FPG、TG、TCH（P〈0.05）. There is a positive correlation between FFA and Hb A1 c in PE group（r=0.768）. Further more there is also a positive correlation bwteen the concentration of FFA and Hb A1 c and severity of Preelampsia（r=0.668、0.528）. Conclusion：There is a close correlationship between high free fatty acid（FFA）and high glycosylated hemoglobin（Hb A1c）and preeclampsia abnormal glucose lipid metabolism. It is of critical clinical guidiance for combination of monitoring to be awareness of preeclampsia abnormal glucose lipid metabolism occurrence and development、expected results.

关 键 词：游离脂肪酸 糖化血红蛋白 子痫前期 糖脂代谢异常 

分 类 号：R714.244[医药卫生—妇产科学]