解脲脲原体和沙眼衣原体感染对男性不育影响的Meta分析  

The increased risk of Ureaplasma urealyticum and Chlamydia trachomatis infection on male infertility:a Meta-analysis

作　　者：杨华君[1] 惠亚 施尚鹏 石修权[1] 

机构地区：[1]遵义医学院公共卫生学院流行病与卫生统计教研室

出　　处：《中国男科学杂志》2015年第5期36-42,共7页Chinese Journal of Andrology

基　　金：贵州省科技厅、遵义医学院、遵义市科技局联合基金资助项目(黔科合J字LKZ[2010]32号);贵州省卫生厅优秀医学青年科技人才基金(gzwkj2010-2-001号)

摘　　要：目的探讨解脲脲原体、沙眼衣原体和男性不育之间的关系。方法运用计算机检索和手工检索相结合的方法，系统检索1994年1月至2014年5月关于男性不育的文献。数据库包括中国生物医学文献数据库（CBM）、中国知网（CNKI）、万方（Wanfang）以及维普（VIP）；Pubmed、Cochranelibrary、Highwire以及Googlescholar。按照纳入及排除标准筛选文献后运用Statal2．0软件对提取数据进行Meta分析。结果最终纳入文献42篇，其中仅含有UU的26篇，仅含有CT的7篇，两者都有的9篇。UU感染对男性不育的汇总效应OR=5．03，95％CI=4．45～5．69（p〈0．001），而CT感染得到的汇总效应OR=4．34，95％CI=3．03～6．23（P〈0．001），两个因素对男性不育的影响均有统计学意义。结论UU感染和CT感染均为男性不育的危险因素，感染者不育风险分别增加5．03倍和4．34倍。Objective To explore the relationship between ureaplasma urealyticum or Chlamydia trachomatis and male infertility. Methods The studies related to male-infertility between January 1994 to May 2014 were searched from databases such as China Biology Medicine disc （CBM）, China National Knowledge Infrastructure （CNKI）, Wanfang and VIP, Pubmed, Cochrane library, Highwire and Google scholar by computer retrieval and a manual retrieval. The eligible studies were further screened by inclusion and exclusion criteria and used for Meta-analysis using Stata 12.0. Results Total of 42 studies were screened for final Meta-analysis, including 26 on UU infection, 7 on CT infection, while 9 on both infection. The combined OR of UU and CT infection on male infertility was 5.03 （95% CI： 4.45 ～5.69） and 4.34 （95% CI： 3.03～ 6.23）, respectively. Both UU and CT infection had significantly increased the risk of male infertility （P 〈0.001）. Conclusion UU infection and CT infection are risk factors of male infertility. The risk of male infertility in patients who infected with UU and CT will increase 5.03 times and 4.34 times, respectively.

关 键 词：解脲支原体 衣原体 沙眼 不育 男性 

分 类 号：R375[医药卫生—病原生物学] R374[医药卫生—基础医学]