不孕不育患者HOXA10基因分析  

Polymorphism of HOXA10 gene among female infertility patients

作　　者：符免艾 黄林[2] 冼梅兰 周立花 胡英 李娟 张云霞[2] 

机构地区：[1]海南省农垦总医院生殖科,海南海口571100 [2]海南医学院

出　　处：《中国公共卫生》2015年第7期958-959,共2页Chinese Journal of Public Health

基　　金：海南省卫生厅科研项目(13A200036)

摘　　要：目的探讨不孕不育女性患者中HOXA10基因多态性。方法选择2013年7月—2014年7月在海南省农垦总医院生殖医学中心进行治疗的女性不孕不育患者220例,采集其空腹外周静脉血,提取基因组DNA,检测其HOXA10基因启动子区SNP位点rs3779456多态性并进行统计分析。结果 CC.CT.TT3种基因型分布频率分别为36.36%,20.91%,42.73%,等位基因C和T出现的频率分别为46.82%和52.18%。结论 HOXA10基因启动子区基因多态性位点rs3779456在海南不孕不育人群中存在2种等位基因3种基因型。Objective To explore the polymorphism of HOXA10 gene among female infertility patients in Hainan province. Methods We selected 220 female infertility patients seeking medication in a hospital during 2013 July to July2014 and collected their venous blood samples for genomic DNA extraction and analysis of single nucleotide polymorphism（ SNP） of rs3779456 of HOXA10 gene. Results The frequencies of CC,CT,and TT of rs3779456 of HOXA10 were 36. 36%,20. 91%,and 42. 73% among patients and the allele frequency of C and T were 46. 82% and 52. 18%.Conclusion There are three genotypes for 2 alleles of rs3779456 of HOXA10 gene among female infertility patients in Hainan province.

关 键 词：HOXA10 不孕不育 分子流行病学研究 

分 类 号：R711.6[医药卫生—妇产科学]