拉莫三嗪添加治疗儿童癫痫的疗效与安全性Meta分析  

Meta analysis of efficacy and safety of lamotrigine as additional therapy for sizures in children

作　　者：田怀平[1] 宗云龙[2] 张金莲[1] 高蕙敏 唐跃年[1] 

机构地区：[1]上海交通大学医学院附属新华医院药学部,上海200092 [2]上海中医药大学中药学院,上海201302

出　　处：《西北药学杂志》2015年第4期429-432,共4页Northwest Pharmaceutical Journal

摘　　要：目的评价拉莫三嗪添加治疗儿童癫痫的疗效和安全性。方法检索PubMed、EMbase、Cochrane图书馆、维普、万方、中国生物医学文献数据库和中国期刊全文数据库,检索时限为从建库起至2014年10月,收集拉莫三嗪添加治疗儿童癫痫的临床试验。由两位研究者按照纳入与排除标准,进行文献筛选、资料提取和纳入研究的方法学质量评价。采用RevMan 5.2软件进行Meta分析。结果共纳入5项研究,375例患儿。Meta分析结果显示:拉莫三嗪添加治疗儿童癫痫有效率高于丙戊酸单药治疗,与拉莫三嗪单药有效率相当。添加治疗不增加不良反应发生率。结论拉莫三嗪添加治疗儿童癫痫疗效确切,耐受性较好。对抗癫痫疗效不佳或使用丙戊酸受限的患儿,拉莫三嗪添加治疗是一种较好的选择。Objective To assess the efficacy and safety of lamotrigine additional therapy for children with seizures.Methods Literatures were retrieved from PubMed,EMbase,the Cochrane Library,VIP,Wanfang database,CBM and CNKI,electronically,searched from the beginning to October 2014.Two reviewers independently screened the literature according to the inclusion and exclusion criteria,extracted the data,and assessed methodological quality.Meta-analysis was performed using RevMan 5.2.Results Five trials were included involving a total of 375 patients.The results of Meta-analysis showed that：the effective rate of lamotrigine additional therapy for seizure in children was better than valproic acid therapy alone,and no significant difference with lamotrigine therapy alone.Lamotrigine additional therapy didn′t increase the adverse reaction rates.Conclusions Lamotrigine additional therapy was effective for seizures in children,and was well tolerated.Lamotrigine was a good choice for children patients who showed poor effect or intolerable adverse related to valproic acid.

关 键 词：拉莫三嗪 丙戊酸 癫痫 儿童 META分析 

分 类 号：R969.3[医药卫生—药理学]