慷舒灵凝胶、莫匹罗星或乳酸依沙吖啶治疗糖尿病足的疗效与安全性比较  

Comparative Study on the Efficacy and Safety of Kangshuling Gel,Mupirocin and Lactate Ethacridine for Diabetic Foot

作　　者：梁桂林[1] 刘露[1] 刘占奎[1] 徐新[1] 

机构地区：[1]齐齐哈尔市第一医院药学部,黑龙江齐齐哈尔161005

出　　处：《中国药房》2015年第21期2896-2898,共3页China Pharmacy

基　　金：黑龙江省卫生厅科研课题(No.2013423)

摘　　要：目的:比较慷舒灵凝胶、莫匹罗星或乳酸依沙吖啶治疗糖尿病足的临床疗效与安全性。方法:将90例糖尿病足患者随机均分为慷舒灵组、莫匹罗星组和乳酸依沙吖啶组。所有患者均给予降糖、营养支持、改善微循环及抗感染等治疗。在此基础上,3组患者分别给予慷舒灵凝胶、莫匹罗星软膏、乳酸依沙吖啶溶液纱布湿敷。各组疗程均为180 d。观察各组患者临床疗效,治疗前后创面面积,痊愈患者肉芽产生时间、上皮组织出现时间及痊愈时间,并记录不良反应发生情况。结果 :慷舒灵组患者总有效率显著高于莫匹罗星组和乳酸依沙吖啶组,痊愈患者肉芽产生时间、上皮组织出现时间及痊愈时间均显著短于莫匹罗星组和乳酸依沙吖啶组,差异均有统计学意义(P<0.05)。治疗后,各组患者创面面积均显著小于同组治疗前,且慷舒灵组小于莫匹罗星组和乳酸依沙吖啶组,差异均有统计学意义(P<0.05);但莫匹罗星组和乳酸依沙吖啶组比较,差异无统计学意义(P>0.05)。各组患者治疗期间均未见明显不良反应发生。结论:在常规治疗的基础上,慷舒灵凝胶治疗糖尿病足较莫匹罗星或乳酸依沙吖啶疗效更显著,安全性较好。OBJECTIVE：To compare the clinical efficacy and safety of Kangshuling gel,mupirocin and lactate ethacridine in the treatment of diabetic foot. METHODS：90 patients with diabetic foot were randomly divided into Kangshuling group,mupirocin group and lactate ethacridine group. All the patients were treated by lowing blood glucose,nutritional support,improving microcirculation and anti-infection,etc. On this basis,3 groups were given Kangshuling gel,Mupirocin ointment and Lactate ethacridine solution for wet compress by gauze. The course was 180 d. The clinic data was observed,including clinical efficacy,and wound area,healed patients＇ granulation,epithelial tissue,healing time and incidence of adverse reactions before and after treatment. RESULTS：The total effective rate in Kangshuling group was significantly higher than mupirocin group and lactate ethacridine group;healed patients＇ granulation,epithelial tissue and healing time were significantly shorter than mupirocin group and lactate ethacridine group,with significant differences（P〈0.05）. After treatment,wound area in each group were significantly smaller than before,and Kangshuling group was smaller than mupirocin group and lactate ethacridine group,with significant differences（P〈0.05）;there were no significant differences between mupirocin group and lactate ethacridine group（P〉0.05）. There were no obvious adverse reactions during treatment. CONCLUSIONS：Based on the conventional treatment,Kangshuling gel has better efficacy than mupirocin and lactate ethacridine in the treatment of diabetic foot,with good safety.

关 键 词：糖尿病足 慷舒灵凝胶 莫匹罗星 乳酸依沙吖啶 

分 类 号：R587.2[医药卫生—内分泌]