大剂量丙种球蛋白联合纳洛酮治疗乙型脑炎疗效分析  

Therapeutic efficacy of high-dose phleboclysis of γ-globulin combined with naloxone in treatment of encephalitis B

作　　者：杨晓燕[1] 邹月新 常明[1] 段武琼[1] 张亚莉[1] 

机构地区：[1]安康市中心医院,陕西安康725000

出　　处：《中国妇幼健康研究》2015年第3期562-563,共2页Chinese Journal of Woman and Child Health Research

摘　　要：目的观察大剂量丙种球蛋白联合纳洛酮治疗乙型脑炎的疗效。方法安康市中心医院2012年6月至2014年9月收治的95例乙型脑炎患儿随机分成两组。对照组47例,给予常规综合治疗(抗病毒治疗+营养支持+对症治疗);研究组48例,在常规综合治疗的基础上,给予丙种球蛋白静脉输注1g·kg^(-1)·d^(-1)联合纳洛酮(0.01~0.02)mg/kg治疗。结果研究组患儿平均退热时间、抽搐时间及意识障碍持续时间较对照组明显缩短(t值分别为4.526、3.371、4.487,均P<0.01);研究组较对照组呼吸衰竭发生率明显降低(x^2=14.341,P<0.05);研究组治愈率显著高于对照组(x^2=19.234,P<0.01)。结论丙种球蛋白联合纳洛酮治疗乙型脑炎较单纯综合治疗更为有效,能够显著降低死亡率,提高治愈率,减少后遗症的发生,应在临床治疗中普遍推广及应用。Objective To observe the therapeutic efficacy of high-dose phleboclysis of γ-globulin combined with naloxone on treatment of encephalitis B. Methods From June 2012 to September 2014 95 children suffering epidemic encephalitis B were admitted in Ankang Central Hospital, and they were divided into control group （47 cases） receiving routine comprehensive treatment （RCT） （antivirus therapy＋ nutrition support ＋ symptom treatment） and study group （48 cases） treated with RCT plus γ-globulin 1g·kg-1 ·d-1 combined with naloxone [（0. 01-0. 02）mg/kg]. Results The average time for pyretolysis, convulsion time and conscious disturbance in the study group were significantly shorter than those of the control group （t value was 4. 526, 3. 371 and 4. 487, respectively, all P 〈0. 01）. The incidence of respiratory failure in the study group was lower than that in the control group （χ2 =14. 341,P〈0. 05）, but the cure rate was significantly higher in the study group （χ2 =19. 234,P〈0. 01）. Conclusion Intravenous infusion of γ-globulin combined with naloxone in the treatment of encephalitis B has better efficacy than simple RCT, and it can reduce mortality obviously, improve cure rate and reduce the incidence of sequela. It should be popularized and applied in clinics.

关 键 词：乙型脑炎 丙种球蛋白 纳洛酮 死亡率 后遗症 

分 类 号：R722[医药卫生—儿科]