别嘌醇改善非高尿酸血症慢性心力衰竭患者运动耐量62例  

Allopurinol for Ameliorating Exercise Tolerance of Non-Hyperuricemic Patients with Chronic Heart Failure in 62 Cases

作　　者：李均[1] 张颖[1] 徐艺[1] 王均生[1] 肖骏[1] 

机构地区：[1]重庆市急救医疗中心,重庆400014

出　　处：《中国药业》2015年第14期22-23,共2页China Pharmaceuticals

基　　金：重庆市卫生计生委医学科研计划项目;项目编号:20140283

摘　　要：目的观察别嘌醇对非高尿酸血症慢性心力衰竭患者运动耐量的影响。方法将医院2008年7月至2013年6月收治的125例非高尿酸血症慢性心力衰竭患者随机分为治疗组62例与对照组63例。对照组患者采用标准抗心力衰竭药物,治疗组患者在对照组基础上加用别嘌呤300 mg/d,均治疗6个月。结果治疗6个月后,治疗组和对照组心功能分级改善分别为(2.33±0.41)和(2.02±0.30),6 min步行距离增加分别为(358.32±53.74)m和(422.61±46.78)m,Tei指数分别降低(0.84±0.12)和(0.64±0.08),血浆脑钠肽(BNP)水平分别下降(911.2±406.5)pmol/L和(544.7±377.8)pmol/L;左心室内径分别缩小(64.8±9.7)mm和(62.5±9.8)mm,左室射血分数(LVEF)分别增加(40.1±11.3)%和(44.5±12.7)%,组间比较,差异均有统计学意义(P<0.05)。对照组和治疗组患者血尿酸均降低[(327.9±58.1)μmol/L和(305.6±52.9)μmol/L],但差异无统计学意义(P>0.05)。结论非高尿酸血症慢性心力衰竭患者加用别嘌醇治疗6个月后可显著改善左心功能及运动耐量。Objective To observe the influence of allopurinol on the exercise tolerance in non- hyperuricemic patients with chronic heart failure. Methods Totally 125 patients admitted to the hospital from July 2008 to June 2013 were randomly divided into the treatment group（ 62 cases） and the control group（ 63 cases）. The control group adopted the standard anti- heart failure drugs,while on this basis the treatment group was added with allopurinol 300 mg / d. The two groups were treated for 6 months. Results The improvement of the NYHA cardiac function grade after 6- month treatment in the treatment group and the control group were（ 2. 33 ± 0. 41） and（ 2. 02 ±0. 30） respectively; the 6 min walking distance was increased by（ 358. 32 ± 53. 74） m and（ 422. 61 ± 46. 78） m respectively; the Tei index was decreased by（ 0. 84 ± 0. 12） and（ 0. 64 ± 0. 08） respectively; the plasma BNP was declined by（ 911. 2 ± 406. 5） and（ 544. 7 ± 377. 8） respectively; the left ventricular internal diameter was shrunk by（ 64. 8 ± 9. 7） mm and（ 62. 5 ± 9. 8） mm; LVEF was increased by（ 40. 1 ± 11. 3） % and（ 44. 5 ± 12. 7） %. The above differences were statistically significant（ P〈0. 05）. The plasma uric acid level after treatment in the two groups was decreased [（ 327. 9 ± 58. 1） μmol / L and（ 305. 6 ± 52. 9） μmol / L ],but without statistical significance（ P〈0. 05）. Conclusion Adding allopurinol for 6 months can significantly ameliorate the left ventricular functions and exercise tolerance in non- hyperuricemic patients with chronic heart failure.

关 键 词：别嘌醇 心力衰竭 尿酸 运动耐量 

分 类 号：R969.4[医药卫生—药理学] R971.1[医药卫生—药学]