舒芬太尼两种用药方法用于颅骨修补术麻醉效果评价  

Anesthetic Effect of Two Different Administration Methods of Sufentanil in Cranioplasty

作　　者：郑吉卫[1] 朱琼[1] 龚璇[1] 亢留玉[1] 徐伟[1] 

机构地区：[1]湖北省荆州市第一人民医院麻醉科,湖北荆州434000

出　　处：《中国药业》2015年第14期63-64,共2页China Pharmaceuticals

摘　　要：目的观察舒芬太尼两种用药方法在颅骨修补术中的麻醉效果及对麻醉恢复的影响。方法选择2012年1月至2014年8月收治的110例颅骨修补术患者,按照数字列表法随机均分为持续给药组(A组)和间断给药组(B组)。两组均给予丙泊酚与维库溴铵,其中A组55例患者采用微泵持续静脉滴注舒芬太尼0.4μg/(kg·h),B组55例患者采用间断静脉注射舒芬太尼0.4μg/kg。结果与诱导前比较,两组患者切皮时、钻骨时心率与血压水平均明显降低(P<0.05),而拔管时则无明显变化(P>0.05);B组患者苏醒时间为(7.98±2.16)min,明显短于A组的(11.52±4.41)min(t=6.82,P<0.05);B组患者定向力恢复时间为(11.38±3.39)min,明显短于A组的(17.89±4.04)min(t=7.46,P<0.05);B组患者拔管时间为(13.07±3.28)min,明显短于A组的(20.38±4.92)min(t=8.97,P<0.05)。结论在颅骨修补术中采用舒芬太尼麻醉,临床效果较好,其中采用间断给药麻醉恢复效果更好,且疗效安全可靠,值得推广。Objective To observe the anesthetic effect of two different administration method of sufentanil in cranioplasty. Methods 110 cases of cranioplasty in the hospital from January 2012 to August 2014 were selected and divided into the continuous medication group（ A） and intermittent medication group（ B） according to the random number table method. The two groups were given propofol and vecuronium, in which the continuous medication group（ 55 cases） adopted the micro- pump continuous intravenous drip of sufentanil0. 4 μg /（ kg · h）, while the intermittent medication group（ 55 cases） was given the intermittent intravenous injection of sufentanil0. 4 μg / kg. Results The heart rate and blood pressure level at the time point of skin incision and drilling the bone in the two groups were significantly decreased compared with before induction（ P〈0. 05）; the heart rate and blood pressure levels at the time of extubation in the two groups had no significant changes compared with before induction（ P〉0. 05）; the recovery time in group B was（ 7. 98 ± 2. 16） min,which was significantly shorter than（ 11. 52 ± 4. 41） min in group A,the difference was statistically significant（ t =6. 82, P〈0. 05）; the orientation recovery time in group B was（11. 38 ± 3. 39） min,which was significantly shorter than（17. 89 ± 4. 04） min in group A,（ t = 7. 46, P〈0. 05）; the extubation time in group B was（ 13. 07 ± 3. 28） min, which was significantly shorter than（ 20. 38 ± 4. 92） min in group A（ t = 8. 97, P〈0. 05）. Conclusion ： Using sufentanil anesthesia in cranioplasty achieves good clinical results,in which the intermittent medication method has better recovery effect with safety and reliability and is worth promoting.

关 键 词：颅骨修补术 舒芬太尼 麻醉效果 麻醉恢复 给药方法 

分 类 号：R969.4[医药卫生—药理学] R971.2[医药卫生—药学]