铜胺络合物催化合成取代2-氨基-2'-羟基-1,1'-联萘类化合物  

Synthesis of A Series of Substituted 2-Amino-2'-Hydroxy-1,1'-Binaphthyl Compounds Catalyzed by Copper-Amine Complex

作　　者：陈之朋[1] 刘叔文[1] 

机构地区：[1]南方医科大学药学院∥广东省新药筛选重点实验室,广东广州510515

出　　处：《中山大学学报（自然科学版）》2015年第4期79-83,共5页Acta Scientiarum Naturalium Universitatis Sunyatseni

基　　金：国家自然科学基金资助项目(81202544)

摘　　要：采用Cu Cl2·2H2O和苄胺(摩尔比为1∶4)的络合物作为氧化偶合试剂,甲醇作溶剂,室温下以取代2-萘酚与2-萘胺为原料进行氧化偶合反应,以中等产率得到一批结构新颖的含取代基的NOBIN类似物,目标产物以沉淀析出,反应后处理简单。产物结构经核磁、质谱确证。A serious of substituted NOBIN compounds were synthesized from substituted 2-naphthol and2-naphthylamine in methanol solvent at room temperature,using the Cu Cl2·2H2O / benzylamine complex with molar ratio of 1∶ 4 as a catalyst. The product with mediate yields was purified by precipitation. The chemical structure was characterized using NMR spectroscopy and FAB-MS analysis.

关 键 词：铜胺络合物 氧化偶合反应 2-氨基-2'-羟基-1 1'-联萘 合成 

分 类 号：R284.1[医药卫生—中药学]