宁夏2012年学龄前儿童脊髓灰质炎中和抗体水平调查  

The investigation of poliomyelitis neutralized antibody level among preschool children in Ningxia hui autonomous region

作　　者：陈慧[1] 刘吉祥[1] 袁芳[1] 马江涛[1] 马学旻[1] 张颖[1] 周丽薇[1] 杨媛媛[1] 

机构地区：[1]宁夏疾病预防控制中心,银川750004

出　　处：《中华实验和临床病毒学杂志》2015年第3期222-224,共3页Chinese Journal of Experimental and Clinical Virology

基　　金：宁夏科技支撑项目（2013ZYS119）

摘　　要：目的 了解宁夏学龄前儿童脊髓灰质炎（脊灰）抗体水平,评价脊灰糖丸疫苗常规免疫效果.方法 用微量细胞中和试验法对12个县（区）的学龄前儿童进行脊灰中和抗体水平检测.结果 共检测462份0～6岁儿童的血清标本.脊灰Ⅰ、Ⅱ、Ⅲ型中和抗体阳性率分别为98.70％、98.48％和97.19％;抗体几何平均滴度（GMT）分别是1∶350.28、1∶241.82和1∶153.94.城乡、各县（区）间抗体阳性率差异无统计学意义.结论 宁夏学龄前儿童通过常规免疫,对脊灰病毒已形成免疫屏障。Objective To understand the neutralized antibody level of the poliomyelitis among preschool children and evaluate the effectiveness of routine immunization in Ningxia.Methods The poliomyelitis antibody were detected using neutralization test among preschool children of 12 counties in Ningxia.Results The positive rates of neutralized antibody were 98.70 %,98.48%,97.19% and GMT were 1 ∶ 350.28,1 ∶ 241.82,1 ∶ 153.94 for polio Ⅰ,Ⅱ,Ⅲ respectively in 462 serum specimens from 0-6 years children.There were no statistical significance difference of antibody positive rate in those counties.Conclusion The immune level of poliomyelitis among preschool children was hign in Ningxia,and the protective barrier had been built against polio virus.

关 键 词：脊髓灰质炎 免疫 主动 抗体 病毒 

分 类 号：R186[医药卫生—流行病学]