基于甲型流感病毒核蛋白的抗病毒靶点研究进展  

Development of Targets for Anti-influenza Virus Based on Nucleoprotein

作　　者：黄智生[1] 孙坚[1] 

机构地区：[1]南昌大学第四附属医院,南昌330003

出　　处：《病毒学报》2015年第4期450-456,共7页Chinese Journal of Virology

基　　金：江西省教育厅科学技术研究项目基金(GJJ13194)

摘　　要：甲型流感是对人类健康和社会稳定构成极大威胁的急性呼吸道传染病,具有极高的发病率和死亡率。由于甲型流感病毒的高变异性和频繁的耐药性,使得新靶点的抗病毒药物的研发显得非常重要。甲型流感病毒的核蛋白高度保守,是一个潜在的抗病毒药物的靶点,国内外已有相关报道。中草药作为祖国的传统医学宝藏,在防治甲流方面也表现出了独特的优势。本文从甲型流感病毒结构与功能出发,阐述甲型流感病毒核蛋白作为抗病毒靶点的研究进展。The influenza A is an acute respiratory infection persistently threatening human health and social stability,and has caused high morbidity and mortality.The development of novel anti-influenza drugs based on new targets is very significant because of high mutation and drug resistance of influenza virus.The nucleoprotein of influenza A virus identified high conservation,provides cross immune protection as a potential target of anti-influenza drugs and reports on relevant studies have been published at home and aboard.Herbal drug as a traditional Chinese medicine shows the distinct advantages in the aspect of prevention and treatment of influenza A.This paper analyzes the structure and function of influenza a virus,and reviews the advances in the research on anti-influenza targets based on the nucleoprotein of the influenza A virus.

关 键 词：甲型流感病毒 核蛋白 抗病毒药物 

分 类 号：R373.9[医药卫生—病原生物学]