脑震荡综合征患者脑网络效率的变化  

Alterations of brain network efficiency in patients with post-concussion syndrome

作　　者：彭楠 钱若兵 傅先明 李顺利 亢志强 林彬 季学兵[2] 魏祥品 牛朝诗 汪业汉 

机构地区：[1]安徽医科大学附属省立医院神经外科、脑功能与脑疾病安徽省重点实验室,合肥230001 [2]安徽医科大学附属省立医院影像科,合肥230001 [3]安徽医科大学第三附属医院合肥市滨湖医院神经外科

出　　处：《中华医学杂志》2015年第25期1972-1975,共4页National Medical Journal of China

基　　金：国家自然科学基金（30670683,30973084）;安徽省自然科学基金（11040606M167）;安徽省科技攻关计划（1301042201）;安徽省重点实验室绩效考核项目（1306c083028）

摘　　要：目的 探讨采用图论的方法对脑震荡综合征患者脑网络效率的改变.方法 2013年6月至2014年3月在安徽医科大学附属省立医院就诊的脑震荡综合征患者23例,有迁延不愈的头晕、头痛、注意力下降、注意力不集中、记忆下降、睡眠障碍等功能障碍,另招募23例健康对照者;两组被试进行Stroop色词实验了解选择性注意功能是否存在差别;采集两组静息态功能磁共振（restingstate fMRI）数据,使用GRETNA软件中Network Construction模块进行数据预处理得到脑网络的矩阵,运用Network Analysis模块进行脑网络分析,得到网络效率属性,并在阈值为0.05≤Sparsity≤0.4范围内比较脑网络效率的改变.结果 Stroop色词实验中脑震荡综合征患者存在选择性注意功能障碍（P＜0.05）;与健康被试相比,脑震荡综合征患者全脑网络效率在各阈值下未见降低,但是在左侧眶部额中回、左侧后扣带回、左侧舌回、左侧丘脑、左侧颞上回、右侧前扣带回、右侧后扣带回及右侧缘上回的脑区效率发生改变.结论 脑震荡综合征患者全脑功能网络效率未见改变,但局部脑区效率下降,可能是导致选择性注意功能下降的原因.Objective To discuss the alterations of brain network efficiency in patients with postconcussion syndrome.Methods A total of 23 patients from Anhui Provincial Hospital in the period from 2013/6 to 2014/3 who have had the concussion for 3 months were enrolled and 23 volunteers paired in sex,age and education were also enrolled as healthy controls.Comparisons of selective attention of both groups were conducted using Stroop Word-Color Test.The data of resting-state functional magnetic resonance imaging （fMRI） in both groups were collected and the data were dealt with Network Construction which is a part of GRETNA software to obtain the Matrix of brain network.Network analysis was used to obtain Global and Nodal efficiency,then independent t-test was used for statistical analyses of the value of Global and Nodal efficiency.Results The difference in Global efficiency of two groups in every threshold value had no statisticalsignificance.Compared with healthy controls,the Nodal efficienciesin patients with post-concussion syndrome weresignificantly different in the brain regionsas below：left orbital middle frontal gyrus,left posterior cingulate,left lingual,left thalamus,left superior temporal gyrus,right anterior cingulate,right posterior cingulate,right supramarginalgyrus.Conclusions Compared with healthy controls,there is no significant changes of Globe efficiency in patients with post-concussion syndrome,and the brain function deficits in these patients may be caused by changes of Nodal efficiency in their brain network.

关 键 词：脑震荡后综合征 脑图 磁共振成像 注意力 

分 类 号：R651.15[医药卫生—外科学]