糖尿病肾病患者血清RBP4水平与颈动脉病变的相关性分析  

The Correlation Analysis of Serum RBP4 Level with Carotid Artery Lesions in Patients with Diabetic Nephropathy

作　　者：张瑜珊[1] 汪年松[1] 王筱霞[1] 

机构地区：[1]上海交通大学附属第六人民医院肾脏内科,上海200233

出　　处：《中国中西医结合肾病杂志》2015年第6期495-498,共4页Chinese Journal of Integrated Traditional and Western Nephrology

基　　金：国家自然基金面上项目(No.81270824);上海市国际科技合作基金资助项目(No.11410708500);上海市科委基金资助项目(No.11DZ1921904);上海市科委基础研究重大项目(No.11DJ1400101);上海市科委重大项目(No.11DZ1973103)

摘　　要：目的：探讨糖尿病肾病（DN）患者血清RBP4水平与颈动脉病变的相关性。方法：收集2013年~2014年本院住院DN患者345例,应用独立样本间t检验、双变量相关分析以及Pearson’s检验对患者血清RBP4水平和颈动脉病变的相关性进行分析。结果：随着血清RBP4水平上升,颈动脉斑块、颈动脉狭窄发病率上升,平均颈动脉内膜中层厚度与颈动脉斑块、狭窄、e GFR相关（P〈0.05）;RBP4水平与CIMT差异无统计学意义（P〉0.05）。结论：血清RBP4水平与DN患者颈动脉斑块、狭窄发病率呈正相关。Objective：The aim of this study was to explore the correlation of the serum RBP4 level with carotid artery le-sions in patients with diabetic nephropathy. Methods：We investigated serum levels of RBP4 and carotid artery lesions by ultrasound in hospitalized 345 DN patients. And we applied independent sample t - test,bivariate correlation analysis and Pearson’- s test to valuate the correlation of serum RBP4 levels and carotid artery lesions. Results：With the elevation of serum levels of RBP4,the inci-dence of both carotid artery plaques and lesions increased accordingly whereas the carotid intima - media thickness showed no signifi-cant difference with the levels of serum RBP4 remarkably（P ﹥ 0. 05）. Conclusion：The serum levels of RBP4 showed a positive cor-relation with the carotid artery plaques and stenosis lesions in DN patents.

关 键 词：糖尿病肾病 视黄醇结合蛋白4 颈动脉斑块 狭窄 

分 类 号：R587.2[医药卫生—内分泌] R692.9[医药卫生—内科学]