血清胱抑素C联合β_2-MG检测对糖尿病肾病早期诊断的价值  

Research on the Value of Serum Cystatin C Combined with β_2-MG Assay in Early Diagnosis of Diabetic Nephropathy

作　　者：胡贵贤[1] 金红君[2] 

机构地区：[1]贵阳护理职业学院门诊部,贵州贵阳550081 [2]重庆医科大学检验医学院,重庆400016

出　　处：《贵阳医学院学报》2015年第7期718-720,共3页Journal of Guiyang Medical College

摘　　要：目的:探讨血清胱抑素C(Cys C)联合β2微球蛋白(β2-MG)检测在糖尿病肾病(DN)早期诊断中的价值。方法:以尿微量白蛋白/尿肌酐比值(MAlb/Cr)为依据将73例糖尿病患者分为单纯糖尿病组、DN早期组及DN组,设健康对照组;比较各组血清Cys C、β2-MG、尿素(Urea)及肌酐(Scr)的变化及在各组中阳性率,分析血清Cys C、β2-MG、尿MAlb/Cr三者间的相关性。结果:DN早期组Cys C、β2-MG含量较单纯糖尿病组升高,差异有统计学意义(P﹤0.05,P﹤0.01);阳性率仅在DN早期组血清Cys C、β2-MG明显高于Urea、Scr阳性率,差异有统计学意义(P﹤0.05);血清Cys C与β2-MG、MAlb/Cr间呈正相关(r=0.951、0.804,P<0.05),β2-MG与MAlb/Cr间仍呈正相关(r=0.741,P﹤0.05)。结论:联合检测血清Cys C和β2-MG对DN有较好的早期诊断价值。Objective： To investigate the clinical value of serum Cystatin C combined with β2 -MG in early diagnosis of Diabetic Nephropathy. Methods： Based on MAIb / Cr, 73 diabetic patients were divided into： diabetes without nephropathy group, early diabetic nephropathy group, diabetic nephrop- athy group and control group. Comparing changes and positive rate in the serum Cys C, β2 -MG, U- rea, CR of each group, analyzing correlation among serum Cys C, β2 - MG and MAlb / Cr. Results： Cys C and β2 - MG in early diabetic nephropathy group were higher than diabetic nephropathy group, differences were statistically significance （P 〈 0.05 ,P 〈0.01 ） ; Serum Cys C and β2 -MG positive rates were significantly higher than Urea and Scr positive rates in early diabetic nephropathy group （P 〈 0.05 ） ; Serum Cys C, β2 - MG and MAIb / Cr was positively correlated （ r = 0. 951, 0. 804, P 〈 0. 05 ）, β2 - MG and MAlb / Cr was positively correlated （ r = 0.741,P 〈 0.05 ）. Conclusion： Serum Cys C combined with β2- MG can serve as effective way for early diabetic nephropathy diagnosis.

关 键 词：血清胱抑素C Β2微球蛋白 糖尿病 糖尿病肾病 

分 类 号：R587.2[医药卫生—内分泌]