吸入性皮质类固醇联合茶碱对支气管哮喘疗效观察  

Curatire Effect of Inhaled Corticosteroids Combined with Theophylline on Bronchial Asthma

作　　者：余红[1,2,3] 姚红梅[1,2,3] 叶贤伟[1,2,3] 张程[1,2,3] 徐艳菊 林洁如[1,2,3] 官志忠[4] 张湘燕[1,2,3] 

机构地区：[1]贵州医科大学附属人民医院呼吸与危重症医学科,贵州贵阳550002 [2]贵州省人民医院呼吸与危重症医学科,贵州贵阳550002 [3]贵州省呼吸疾病研究所,贵州贵阳550002 [4]贵州医科大学,贵州贵阳550004

出　　处：《贵阳医学院学报》2015年第7期721-723,726,共4页Journal of Guiyang Medical College

基　　金：科技部国家科技支撑计划课题(No:2013BAI05B03);国家科技支撑计划课题(No:2013BAI06B02);国家科技支撑计划课题(No:2013BAI06B00);贵州2011协同创新中心建设项目[黔教合协同创新中心(2014)06]

摘　　要：目的:评估吸入皮质类固醇联合茶碱在24周内对支气管哮喘病情恶化、控制情况和FEV1%预计值的影响。方法:筛选门诊未控制中度支气管哮喘患者88例,随机平均分为试验组和对照组,试验组吸入布地奈德联合口服缓释型茶碱,对照组吸入布地奈德福莫特罗粉吸入剂,疗程24周;比较两组治疗24周时哮喘急性发作率、治疗前后第1秒用力呼气容量占预计值百分比(FEV1%预计值),并通过哮喘控制测试(ACT)评估哮喘控制情况和生活质量。结果:治疗24周时,试验组与对照组的急性发作次数、ACT评分、FEV1%预计值差异无统计学意义(P>0.05);治疗前后两组组内比较,急性发作次数、ACT评分和FEV1%预计值差异均有统计学意义(P<0.05)。结论:ICS联合茶碱,在控制哮喘急性发作、改善哮喘患者肺功能方面与ICS联合长效β受体激动剂有相似的疗效。Objective： To investigate the effect of low dose theophylline combined with low dose in- haled corticosteroids （ICS） on asthma exacerbations, asthma control , and FEV1% predicted value o- ver 24 weeks. Method：A total of 88 patients with moderate bronchial asthma were randomly assigned in equal number to receive either inhaled budesonide plus oral slow -release theophylline （observe group） or budesonide plus formoterol （ control group） for 24 weeks. Both groups were compared after 24 weeks of the attack frequency and FEV1% predicted value, with ACT scores to evaluate asthma control and life quality. Results：The attack frequency, ACT scores and FEV~ % predicted value of both groups showed no statistical difference in 24 - weeks treatment （P 〉 0.05 ）. There were significant differences in the acute episodes, ACT score and FEV~% predicted value within both groups before and after treatment （P 〈 0.05 ）. Conclusion： ICS combined with theophylline and ICS combined with long- acting beta agonists have similar effect in asthma control and pulmonary function improvement.

关 键 词：吸入皮质类固醇 茶碱 支气管 哮喘 

分 类 号：R562.25[医药卫生—呼吸系统]