支气管扩张试验阳性的COPD患者小气道功能研究  

Study on Small Airway Function in COPD Patients with Positive Bronchial Dilation Test

作　　者：乐文俊[1,2] 张湘燕[1,2] 叶贤伟[1,2] 齐晓岚[3] 张程[1,2] 

机构地区：[1]贵州医科大学附属人民医院呼吸与重症医学科,贵州贵阳550002 [2]贵州省人民医院呼吸与重症医学科,贵州贵阳550002 [3]贵州医科大学分子生物学重点实验室,贵州贵阳550004

出　　处：《贵阳医学院学报》2015年第7期724-726,共3页Journal of Guiyang Medical College

基　　金：国家科技支撑计划课题(2013BAI06B00);国家科技支撑计划课题(2013BAI05B03);十二五国家科技支撑计划课题(2013BAI09B09);贵州省2011协同创新中心建设项目[黔教合协同创新中心(2014)06]

摘　　要：目的:分析慢性阻塞性肺疾病(COPD)合并支气管扩张试验阳性患者小气道通气功能指标,为探讨该病的发病提供依据。方法:住院治疗达到稳定期的单纯COPD患者70例(单纯COPD组),支气管扩张试验阳性COPD患者39例(扩张试验阳性组),比较两组患者性别比例、年龄、体重指数(BMI)及使用沙丁胺醇支气管舒张试验前后第1秒用力呼气量占预计值百分比(FEV 1%)、1秒率(FEV/FVC%)、最大呼气中期流量(MMEF)、50%肺活量时的最大呼气流速(FEF 50%)、25%肺活量时的最大呼气流速(FEF 25%)肺功能指标。结果:扩张试验阳性组年龄<单纯COPD组(P<0.05),吸入沙丁胺醇前扩张实验阳性COPD组MMEF、FEF50%、FEF 25%较单纯COPD组低(P<0.05);吸入沙丁胺醇后这些指标和单纯COPD组比较,差异无统计学意义(P>0.05)。结论:支气管扩张试验阳性的COPD患者发病年龄相对较小,小气道功能较单纯COPD低。Objective： To investigate small airway function index in COPD patients with positive bronchial dilation test, in order to provide clinical data for better understanding the pathogenesis of this disease. Method： Seventy COPD patients in stable stage （single COPD group） and 39 COPD patients with positive bronchial dilation test （dilation positive group） were chosen. Sex ratio, age and BMI in both groups were analyzed. Comparing lung function indexes of FEVI%, FEV/FVC%, MMEF, FEF 50% and FEF 25% before and after salbutamol bronchial dilation test. Results： The age of dilation positive group was younger than single COPD group （ P 〈 0.05 ） , MMEF, FEF50% and FEF25% were lower in dilation positive group than single COPD group before inhalation of salbutamol （P 〈 0. 05 ） while no difference was found in these indexes between the two growps after inhalation of salbuta- mol （P 〉 O. 05 ）. Conclusions： COPD patients with positive bronchial dilation test are younger, their small airway function is worse than COPD group.

关 键 词：慢性阻塞性肺疾病 支气管舒张试验 小气道功能 

分 类 号：R563.9[医药卫生—呼吸系统]