急性心肌梗死后心力衰竭患者心室重构相关的血清标记物分析  

Analysis of ventricular remodeling-related serum biomarkers in patients with heart failureafter acute myocardial infarction

作　　者：顾海波[1] 

机构地区：[1]苏州大学附属第二医院心血管病科,江苏省215004

出　　处：《江苏医药》2015年第13期1539-1541,共3页Jiangsu Medical Journal

摘　　要：目的分析急性心肌梗死(AMI)后心力衰竭患者心室重构相关的血清标记物水平。方法依据随访结局,84例AMI患者分为发生Ⅲ级或Ⅳ级心力衰竭(A组,46例)和未发生Ⅲ或Ⅳ级心力衰竭(B组,38例)。检测并比较两组血清基质金属蛋白酶抑制因子3(TIMP-3)、基质金属蛋白酶1(MMP-1)、转化生长因子β1(TGF-β1)以及N末端B型利钠肽原(NT-proBNP)水平;应用心脏彩色多普勒检测并比较两组患者的左室射血分数(LVEF)、左室舒张末期直径(LVEDD)和左室短轴缩短率(LVFS)等。结果与B组相比,A组LVEF及LVFS较低,TIMP-3、MMP-1、TGF-β1、NT-proBNP及LVEDD较高(P<0.05)。血清TIMP-3和NT-proBNP高表达是严重心力衰竭发生的危险因素(OR=1.024和1.035,P<0.05)。结论血清TIMP-3和NT-proBNP浓度可作为AMI后心力衰竭患者心室重构的独立预测指标。Objective To analyze the ventricular remodeling-related serum biomarkers in the patients with heart failure（HF）after acute myocardial infarction（AMI）.Methods According to the follow-up outcomes,84 patients with AMI were divided into two groups of A（complicated with classⅢ orⅣ HF,46cases）and B（without class Ⅲ or Ⅳ HF,38cases）.The expressions of metalloproteinases tissue inhibiting factor 3（TIMP-3）,matrix metalloproteinase 1（MMP-1）,transforming growth factorβ1（TGF-β1）,and N-terminal pro-brain natriuretic peptide（NT-proBNP）were detected.The left ventricular ejection fraction（LVEF）,left ventricular end-diastolic diameter（LVEDD）and left ventricular fractional shortening（LVFS）were detected by ultrasonic cardiogram.Results Compared to group B,LVEF and LVFS were lower,but TIMP-3,MMP-1,TGF-β1,NT-proBNP and LVEDD were higher in group A（P〈0.05）.The high serum expressions of TIMP-3and NT-proBNP were the risk factors for the occurrence of serious HF（OR=1.024 and 1.035,P〈0.05）.Conclusion Serum levels of TIMP-3and NT-proBNP could be used as the dependent predictors of ventricular remodeling in the patients with HF after AMI.

关 键 词：急性心肌梗死 心力衰竭 心室重构 基质金属蛋白酶抑制因子3 N末端B型利钠肽原 

分 类 号：R541[医药卫生—心血管疾病]