系统性红斑狼疮患者血清中肺炎衣原体感染的检测  

Detection of Chlamydia Pneumoniae Antibodies in Serum of Patients with Systemic Lupus Erythematosus

作　　者：梅莉红[1] 干慧慧[1] 翁孟武[2] 方芳[1] 

机构地区：[1]复旦大学附属金山医院皮肤科,上海201508 [2]复旦大学附属华山医院皮肤科,上海200040

出　　处：《中国皮肤性病学杂志》2015年第7期670-672,680,共4页The Chinese Journal of Dermatovenereology

基　　金：上海市金山区科委资助项目(2011-3-04)

摘　　要：目的调查系统性红斑狼疮(systemic lupus erythematosus,SLE)患者血清中肺炎衣原体(Chlamydia pneumoniac,cpn)的感染状况,探讨肺炎衣原体感染与SLE的相关性。方法酶联免疫法分别检测60例SLE患者和61例健康对照组患者血清肺炎衣原体Ig M,Ig G抗体。结果 SLE组(60例)与对照组(61例)的肺炎衣原体Ig M抗体阳性率分别为8.33%和8.19%,两组相比差异无统计学意义(P>0.05)。两组的肺炎衣原体Ig G抗体1∶40,1∶60,1∶80阳性率对比差异有统计学意义(P<0.01)。结论肺炎衣原体的急性感染与SLE发病无关。Objective To examine the C. pneumoniae infection condition of SLE patients and to investigate the correla- tion between C. pneumoniae infection and SLE. Methods Sixty patients with SLE and sixty-one healthy vol- unteers were enrolled in this study. C. pneumoniae IgM and IgG antibodies in the serum were detected by ELISA. Results The positive rates of C. pneumoniae IgM antibody in the serum of the SLE group （60 ca- ses） and control group （61cases） were 8. 33% and 8. 19% ,respectively. There was no significant difference between two groups （ P 〉 O. 05 ）. C. pneumoniae IgG antibody was detected in the two groups with the follow- ing three dilutions ： 1 ： 40, 1 ： 60, and 1 ： 80. There was a significant difference between two groups （ P 〈 0.01 ）. Conclusions There is no correlation between acute C. pneumoniae infection and the onset of SLE.

关 键 词：系统性红斑狼疮 肺炎衣原体 酶联免疫法 

分 类 号：R593.241[医药卫生—内科学]