基于生物学优化肿瘤放射治疗计划的评估函数  

Evaluation function of radiotherapy plan based on biological optimization

作　　者：张伟[1] 叶奕菁[1] 余建荣[1] 李珍[1] 古定标[1] 

机构地区：[1]中山市人民医院放疗科,广东中山528403

出　　处：《中国医学物理学杂志》2015年第4期599-603,共5页Chinese Journal of Medical Physics

摘　　要：目的:在基于生物学优化肿瘤放射治疗计划的评估函数提出以后,用评估函数选取合适的治疗计划,通过对治疗计划实施结果的评判验证其在临床上的可行性。方法:充分结合临床放疗医生经验与基于生物学优化肿瘤放射治疗计划的评估函数参数值来选择合适的治疗计划,选取鼻咽癌、食管癌和肺癌,对病例随机分组为比较组、超分割组以及适形调强(IMRT)组和容积调强(VMAT)组,然后从生存率、近期疗效、局控率以及近远期毒副作用等方面对病例治疗结果进行统计分析,评估治疗方案的可行性。结果:从近期疗效、局控率、生存率以及近期毒副作用来看,鼻咽癌组全程连续超分割高于其他对照组;对于食管癌后程加速超分割效果最好;对于肺癌是连续超分割组好于其他对照组。这种结果跟治疗前利用评估函数预判的结果一致,即利用评估函数所选取的治疗方案是有效的。结论:基于生物学优化肿瘤放射治疗计划的评估函数用于临床选取治疗方案方面是可行的。Objective To validate the feasibility of evaluation function of radiotherapy plan based on biological optimization in clinical by evaluating results of the treatment plan selected by the evaluation function. Methods The treatment plan was selected based on the comprehensive consideration of the clinical experience of radiotherapy doctors and parameter values of the evaluation function developed in this paper. Patients with nasopharyngeal carcinoma （NPC）, esophageal cancer （EC） and lung cancer （LC） were selected to be randomly divided into comparison group, intensity modulated radiation therapy （IMRT） group and volumetric modulated arc therapy （VMAT） group. And the feasibility of treatment plan was assessed by statistically analyzing the survival rate, short-term curative effect, local control rate, short-term and long-term toxic side effects. Results The analyzed results showed that the whole course continued hyperfractionation in NPC group was higher than that in other groups, and that EC group had the best effect in the late course accelerated hyperfractionation, and that LC group was best in continued hyperfractionation. The analyzed results were consistent with the results calculated by evaluation function before the treatment, so the treatment plan selected by evaluation function was feasible. Conclusion Evaluation function of radiotherapy plan based on biology optimization is feasible to select treatment plan in clinical.

关 键 词：生物学优化 肿瘤放射治疗计划 评估函数 临床应用 

分 类 号：R311[医药卫生—基础医学] R730.55