硫酸钙骨替代材料联合椎弓根钉固定恢复胸腰椎压缩骨折椎体高度  

Calcium sulfate bone substitute combined with pedicle screw fixation for the recovery of vertebral height following thoracolumbar vertebral compression fractures

作　　者：冯杰荣[1] 杜庆钧[1] 

机构地区：[1]南方医科大学附属医院顺德第一人民医院骨科一区,广东省顺德市528300

出　　处：《中国组织工程研究》2015年第25期3972-3976,共5页Chinese Journal of Tissue Engineering Research

摘　　要：背景:硫酸钙骨替代材料具有良好的安全性和生物相容性,植入人体后具备较好的强度,可恢复胸腰椎骨折力学强度,降低椎体高度的丢失且可逐渐被降解吸收。目的:观察硫酸钙骨替代材料联合后路椎弓根钉固定恢复胸腰椎压缩骨折椎体高度的效果。方法:纳入42例T12-L3胸腰椎压缩骨折患者,其中男27例,女15例,年龄21-57岁,均实施硫酸钙骨替代材料联合后路椎弓根钉固定置入治疗,治疗后12个月,对比治疗前后的椎体前缘高度、脊柱后凸Cobb角、Oswestry功能障碍指数评分及目测类比评分情况。结果与结论:随访12个月,所有患者均未出现局部炎症和过敏、刺激反应等,未发生凝血改变和免疫反应等,螺钉无断裂或者松动现象;末次随访椎体前缘高度较治疗前显著增加(P<0.05),末次随访脊柱后凸Cobb角、Oswestry功能障碍指数及目测类比评分较治疗前显著减小(P<0.05)。表明硫酸钙骨替代材料联合后路椎弓根钉固定置入治疗可显著恢复胸腰椎压缩骨折患者的椎体高度,促进患者功能恢复。BACKGROUND： Calcium sulfate bone substitute material has a good safety and biocompatibility, and possesses good strength after implantation to restore thoracolumbar mechanical strength and reduce vertebral height loss, and moreover, it may gradually be degraded and absorbed. OBJECTIVE： To explore the influence of posterior pedicle screw fixation combined with calcium sulfate bone substitute material on the recovery of vertebral height after thoracolumbar vertebral compression fractures. METHODS： Forty-two patients with thoracolumbar vertebral compression fractures（T12-L3） were enrolled to receive posterior pedicle screw fixation combined with calcium sulfate bone substitute, including 27 males and 15 females, aged 21-57 years. All patients were followed-up for 12 months, and then anterior vertebral height, kyphosis Cobb angle, Oswestry disability index score and visual analog scale score before and after treatment were determined and compared. RESULTS AND CONCLUSION： At the end of follow-up, no local complications, no coagulation, no immune response and no screw breakage occurred; the anterior vertebral height, kyphosis Cobb angle, Oswestrydisability index score and visual analog scale score were significantly improved（P〈0.05）. These findings indicate that the posterior pedicle screw fixation combined with calcium sulfate bone substitute can restore the vertebral height and promote functional recovery of patients with thoracolumbar vertebral compression fractures.

关 键 词：生物材料 骨生物材料 硫酸钙骨替代材料 胸腰椎骨折 压缩性骨折 经椎弓根 椎体高度 

分 类 号：R318[医药卫生—生物医学工程]