钴铬合金表面镀氮化锆涂层对细菌黏附性能的影响  

Cobalt-chromium alloy with zirconium nitride coating influences adhesion properties of bacteria

作　　者：桑卓[1] 付玉[1] 陈东[1] 古育娣 陈湘涛[2] 

机构地区：[1]深圳市福田区人民医院口腔科,广东省深圳市518033 [2]佳木斯大学附属口腔医院,黑龙江省佳木斯市154002

出　　处：《中国组织工程研究》2015年第25期4033-4037,共5页Chinese Journal of Tissue Engineering Research

摘　　要：背景:细菌黏附与钴铬合金材料的表面性能密切相关,因此近年来材料的表面改性技术成了该领域的研究重点。目的:验证钴铬合金表面所镀氮化锆薄膜是否可以改善义齿金属材料的细菌黏附性能。方法:应用磁控溅射沉积方法在钴铬合金材料表面镀氮化锆薄膜,制备钴铬合金镀膜组试件(实验组),以未镀膜的钴铬合金试件为对照组,分别将变形链球菌、白色念珠菌和黏液放线菌接种在两组试件的测试面上,待培养结束时进行菌落计数。结果与结论:细菌黏附实验结果显示,实验组3种细菌的菌落计数均低于对照组,差异有显著性意义(P<0.05),对照组的细菌黏附数量明显高于镀膜组。提示:钴铬合金表面所镀氮化锆薄膜可以显著降低变形链球菌、白色念珠菌及黏性放线菌的黏附数量,从而改善钴铬合金材料的细菌黏附性能。BACKGROUND： Bacterial adhesion is closely related to the surface properties of cobalt-chromium alloys, and therefore, the surface modification technology has become the focus of research in this area. OBJECTIVE： To verify whether the cobalt-chromium alloy with zirconium nitride coating can improve the bacterial adhesion of metal denture materials. METHODS： Magnetron sputtering deposition method was used to plate zirconium nitride film on the surface of cobalt-chromium alloys（experimental group）, and cobalt-chromium alloy specimens uncoated served as control group. Streptococcus mutans, Candida albicans, and Actinomyces viscosus were respectively inoculated on the two kinds of test specimen, and at end of culture, the colony counting was done. RESULTS AND CONCLUSION： In the bacterial adhesion test, the number of colonies of three kinds of bacteria in the experimental group was significantly lower than that in the control group（P〈0.05）. The number of bacterial adhesion in the control group was significantly higher than that in the experimental group. These findings indicate that the cobalt-chromium alloy covered with zirconium nitride coating can significantly reduce the adhesion amount of Streptococcus mutans, Candida albicans and Actinomyces viscosus, and thus improve bacterial adhesion properties of cobalt-chromium alloys.

关 键 词：生物材料 口腔生物材料 氮化锆 钴铬合金 细菌黏附 变形链球菌 白色念珠菌 黏性放线菌 表面改性 表面涂层 

分 类 号：R318[医药卫生—生物医学工程]