合成可生物降解神经导管修复损伤周围神经:生物相容性良好  

Synthetic biodegradable nerve conduits for repair of injured peripheral nerve: good biocompatibility

作　　者：张孙富[1] 王斌[2] 

机构地区：[1]宜宾市第一人民医院神经外一科,四川省宜宾市644000 [2]泸州医学院附属医院神经外科,四川省泸州市646000

出　　处：《中国组织工程研究》2015年第25期4054-4058,共5页Chinese Journal of Tissue Engineering Research

摘　　要：背景:临床对周围神经损伤进行修复治疗的时候,可以利用自体神经进行治疗或者利用不同材质的神经导管进行治疗。目的:探索合成可生物降解材料神经导管在周围神经损伤修复中的应用效果。方法:48只新西兰大白兔,随机等分为3组,自体神经移植组、硅胶导管组和可降解神经导管组。各组动物切除10 mm坐骨神经,构建坐骨神经缺损动物模型,并分别利用自体神经、硅胶导管以及可降解神经导管进行坐骨神经修复。结果与结论:造模后3周,硅胶导管组兔运动神经传导效果、小腿三头肌肌肉湿质量恢复率比自体神经移植组差,但可降解神经导管组兔运动神经传导效果、小腿三头肌肌肉湿质量恢复率与自体神经移植组接近。造模后12周时,自体神经移植组中存在大量呈均匀排列的有髓神经纤维,可降解神经导管组中可见大量分布不均匀的再生有髓神经纤维,而硅胶导管组中存在少量呈不均匀排列的髓神经纤维。表明合成可生物降解材料神经导管在周围神经损伤修复中可以获得与自体神经较为接近的良好效果。BACKGROUND： In the treatment of peripheral nerve injury, we can use autologous nerve or the nerve conduit of different materials. OBJECTIVE： To explore the effects of biodegradable nerve conduit in repairing peripheral nerve injury. METHODS： A total of 48 New Zealand white rabbits were randomly divided into autologous nerve graft group, silicone catheter group and biodegradable nerve conduit group. 10-mm sciatic nerve was obtained from each group to construct animal models of sciatic nerve defect, which was repaired with autologous nerve, silicone catheter and biodegradable nerve conduit. RESULTS AND CONCLUSION： At 3 weeks after transplantation, motor nerve conduction and recovery rate of triceps muscle wet weight were poorer in the silicone catheter group than in the autologous nerve graft group. Motor nerve conduction and recovery rate of triceps muscle wet weight were similar between the biodegradable nerve conduit group and autologous nerve graft group. At 12 weeks, a large number of uniform myelinated nerve fiber was visible in the autologous nerve graft group. A large number of uneven myelinated nerve fiber was found in the biodegradable nerve conduit group. A small number of uneven myelinated nerve fiber was seen in the silicone catheter group. These data suggest that the synthetic biodegradable materials of nerve conduit can obtain good effect, which is close to the autologous nerve graft.

关 键 词：生物材料 材料相容性 周围神经 神经损伤 神经修复 组织工程 神经导管 导管材料 合成材料 可降解生物材料 

分 类 号：R318[医药卫生—生物医学工程]