3D打印骨组织工程支架的研究与应用  

3D printing of bone tissue engineering scaffolds

作　　者：曹雪飞[1,2] 宋朋杰 乔永杰[1] 甄平[2] 

机构地区：[1]兰州大学第二临床医学院,甘肃省兰州市730000 [2]解放军兰州军区兰州总医院全军骨科中心,甘肃省兰州市730050

出　　处：《中国组织工程研究》2015年第25期4076-4080,共5页Chinese Journal of Tissue Engineering Research

基　　金：国家自然科学基金面上项目(81371983):多孔β-TCP负载PLGA抗结核药物缓释微球的构建及其抗结核成骨作用研究~~

摘　　要：背景:虽然应用传统方法制作骨组织工程支架取得一定成就,但在支架的三维结构、力学强度、支架个性化方面不太满意,通过3D打印技术制作支架的方法有望改变这些不足。目的:对3D打印技术制作骨组织工程支架作一综述,对支架的未来优化进行展望。方法:应用计算机检索Pub Med和谷歌学术数据库中,2008至2015年关于3D打印技术制作骨组织工程支架的文章。纳入包含骨组织工程支架结构设计、材料及通过不同3D打印技术制作的支架性能研究文章,排除观点重复和陈旧的文章,最后对37篇文献进行归纳总结。结果与结论:目前可用作骨组织工程支架制作的3D打印技术有熔融层积成型、立体平版印刷、选区激光烧结及3DP技术。3D打印技术制作的骨组织工程支架在力学、结构、个性化方面有其独特优势,但该技术仍有很多问题需要解决,比如原材料的问题、不同3D打印技术的不足问题及3D打印机器的改进问题等。相信在未来多学科的共同合作下,可以制作出适合于临床的骨组织工程支架,造福于人类。BACKGROUND： Although bone tissue engineering scaffolds made of traditional methods have made certain achievements, the three-dimensional structure, mechanical strength and personalized property of the scaffolds are unsatisfied. 3D printing technology is expected to change these shortcomings. OBJECTIVE： To review the 3D printing of bone tissue engineering scaffolds and to prospect the optimization of the scaffolds. METHODS： A computer-based search of Pub Med and Google academic database was performed for articles addressing the 3D printing of bone tissue engineering scaffolds published from 2008 to 2015. Articles concerning the structure design and materials of bone tissue engineering scaffolds and different 3D printing technologies for scaffold preparation were included, and repetitive and old articles were excluded. Finally, 37 articles were summarized. RESULTS AND CONCLUSION： Currently, 3D printing technologies used for preparation of bone tissue engineering scaffolds include melt laminated molding, stereolithography, selective laser sintering and 3DPtechnology. 3D printing technologies have unique advantages in mechanics, structure and personalized aspects, but there are still many problems to be solved, such as raw materials, insufficiency of different 3D technologies, and improvement of 3D printer. Under the multi-disciplinary co-operation, 3D printing technology is expected to prepare suitable bone tissue engineering scaffolds and bring benefit to the mankind.

关 键 词：生物材料 骨生物材料 骨缺损 3D打印技术 熔融层积成型术 立体平版印刷术 选区激光烧结术 3DP技术 国家自然科学基金 

分 类 号：R318[医药卫生—生物医学工程]