Pharmacokinetic investigation on nteraction between hydrophilic lithospermic acid B and lipophilic tanshinone IIA in rats:an experimental study  

作　　者：Wang Xiuli Gao Wei Sun Mao 

机构地区：[1]School of Chinese Pharmacy,Beijing University of Chinese Medicine [2]School of Traditional Chinese Medicine,Capital University of Medical Sciences

出　　处：《Journal of Traditional Chinese Medicine》2015年第2期206-210,共5页中医杂志（英文版）

基　　金：Supported by National Natural Science Foundation of China,Common Problem Exploration,Preparation and Evaluation of Salvia Miltiorrhiza-Liquorice Different Polarity Composition Liposomes(No.81202928);Beijing Natural Science Foundation,Preparation and Evaluation of Anti-hepatic Active Targeting Liposomes of Couplet Medicines Salvia Miltiorrhiza-Liquorice(No.7132118)

摘　　要：OBJECTIVE:To elucidate the interaction between hydrophilic lithospermic acid B and lipophilic tanshinone Ⅱ A in rats.METHODS:A reliable high-performance liquid chromatography method was adopted for simultaneous determination of lithospermic acid B and tanshinone Ⅱ A in rat plasma,through which the pharmacokinetic interaction between lithospermic acid B and tanshinone Ⅱ A by intravenous injection was investigated.RESULTS:The simultaneous intravenous injection of tanshinone Ⅱ A and lithospermic acid B significantly altered the pharmacokinetic parameters of both compounds when compared with the individual intravenous administration of each compound.The area under the concentration-time curve of tanshinone Ⅱ A and lithospermic acid B increased by 18.35 and 59.31%,respectively.The mean retention time of tanshinone Ⅱ A and lithospermic acid B increased,respectively,from 9.3 to 32.8 h and20.2 to 49.1 h.The concomitant use of tanshinoneⅡ A magnified the volume of distribution at steady state(V_(ss)) and time for the drug in the plasma to reduce the highest concentration by half(t_(1/2)) of lithospermic acid B,while at the same time the V_(ss) and t_(1/2)of tanshinone Ⅱ A changed significantly in the presence of lithospermic acid B.CONCLUSION:Lithospermic acid B and tanshinone D A interact with each other following simultaneous intravenous injection in rats and this observation may expand the clinical use of Danshen(Radix Salviae Miltiorrhizae).OBJECTIVE：To elucidate the interaction between hydrophilic lithospermic acid B and lipophilic tanshinone Ⅱ A in rats.METHODS：A reliable high-performance liquid chromatography method was adopted for simultaneous determination of lithospermic acid B and tanshinone Ⅱ A in rat plasma,through which the pharmacokinetic interaction between lithospermic acid B and tanshinone Ⅱ A by intravenous injection was investigated.RESULTS：The simultaneous intravenous injection of tanshinone Ⅱ A and lithospermic acid B significantly altered the pharmacokinetic parameters of both compounds when compared with the individual intravenous administration of each compound.The area under the concentration-time curve of tanshinone Ⅱ A and lithospermic acid B increased by 18.35 and 59.31%,respectively.The mean retention time of tanshinone Ⅱ A and lithospermic acid B increased,respectively,from 9.3 to 32.8 h and20.2 to 49.1 h.The concomitant use of tanshinoneⅡ A magnified the volume of distribution at steady state（V_（ss）） and time for the drug in the plasma to reduce the highest concentration by half（t_（1/2）） of lithospermic acid B,while at the same time the V_（ss） and t_（1/2）of tanshinone Ⅱ A changed significantly in the presence of lithospermic acid B.CONCLUSION：Lithospermic acid B and tanshinone D A interact with each other following simultaneous intravenous injection in rats and this observation may expand the clinical use of Danshen（Radix Salviae Miltiorrhizae）.

关 键 词：Tanshinone Lithospermic acid B Pharmacokinetics Drug interactions 

分 类 号：R285.5[医药卫生—中药学]