头孢曲松钠与左氧氟沙星治疗无合并症淋病疗效的对比研究  

Comparative study on the efficacy of ceftriaxone and levofloxacin in the treatment of uncomplicated gonorrhea

作　　者：吴方毅[1] 任妮丽[2] 

机构地区：[1]湖北医药学院附属人民医院皮肤科,湖北十堰442000 [2]湖北医药学院附属人民医院医务科,湖北十堰442000

出　　处：《中国性科学》2015年第7期42-44,共3页Chinese Journal of Human Sexuality

基　　金：湖北省自然科学基金面上项目(2006ABA342)

摘　　要：目的:探讨和比较头孢曲松钠与左氧氟沙星在无合并症淋病患者治疗中的临床应用价值。方法:选取2012年6月至2013年12月期间我院所收治的90例无合并症淋病患者作为本次临床研究对象,采用区组化随机分组法将入选患者随机分为头孢曲松钠组和左氧氟沙星组,每组45例。分别对头孢曲松钠组和左氧氟沙星组无合并症淋病患者的临床治疗情况、不良反应发生情况、预后复发情况进行比较和分析。结果:头孢曲松钠组无合并症淋病患者临床治疗效果达到痊愈标准的比率及总有效率分别为82.22%和97.78%,均显著高于左氧氟沙星组患者的64.44%和77.78%(P<0.05);两组治疗中不良反应发生率不具有显著差异(P>0.05);头孢曲松钠组无合并症淋病患者预后复发的比率为4.44%,明显低于左氧氟沙星组患者的22.22%(P<0.05)。结论:头孢曲松钠在提高无合并症淋病患者临床疗效以及改善预后等方面均优于左氧氟沙星,可作为治疗无合并症淋病患者的推荐药物予以应用和推广。Objectives： To investigate the clinical application value of ceftriaxone and levofloxaein in the treatment of uncomplicated gonorrhea. Methods： 90 uncomplicated gonorrhea patients, from June 2012 to Decem- ber 2013 in our hospital, were selected and divided into ceftriaxone group and levofloxacin group randomly, with 45 cases in each group. The clinical treatment effect, incidence of adverse reactions and ratio of prognosis recurrence of the two groups were compared and analyzed. Results： The ratio of clinical cure and total efficiency of the uncompli- cated gonorrhea patients in ceftriaxone group were 82.22% and 97.78%, respectively. The ratio of clinical cure and total efficiency of the uncomplicated gonorrhea patients in levofloxacin group were 64.44% and 77.78%, re- spectively. The difference was statistically significant （ P 〈 0. 05 ）. The incidence of adverse reactions of the uncom- plicated gonorrhea patients in ceftriaxone sodium group was 11.11%, including diarrhea, abdominal pain, nausea, vomiting and rash itching. The incidence of adverse reactions of the uncomplicated gonorrhea patients in levofloxacingroup was 20.00%, included diarrhea, abdominal pain, nausea, vomiting and rash itching. The difference was not statistically significant （ P 〉 0. 05 ）. The ratio of prognosis recurrence of the uncomplicated gonorrhea patients in ceftriaxone sodium group was 4.44%. The ratio of prognosis recurrence of the uncomplicated gonorrhea patients in levofloxacin group was 22.22%. The difference was statistically significant （P 〈 0. 05 ）. Conclusions： Compared with levofloxacin, ceftriaxone has advantages in improving clinical efficacy, reducing adverse reactions and impro- ving outcomes of patients with uncomplicated gonorrhea, which is worth further application and promotion in the treatment of uncomplicated gonorrhea.

关 键 词：无合并症淋病 头孢曲松钠 左氧氟沙星 

分 类 号：R759.2[医药卫生—皮肤病学与性病学]