降压宝系列中成药治疗原发性高血压的meta分析  

A Meta Analysis of Jiang Ya Bao in Treatment of essential hypertension

作　　者：崔伟锋[1] 王秉权[1] 范军铭[1] 孙现鹏[1] 李星锐[1] 

机构地区：[1]河南省中医药研究院,河南郑州450004

出　　处：《中医药临床杂志》2015年第6期849-850,共2页Clinical Journal of Traditional Chinese Medicine

基　　金：国家自然科学基金资助项目(No.69788090);河南省中医临床学科领军人才(NO.2013-10);国家中医药管理局重点学科建设项目(NO.2008-2013);卫生部重点专科建设项目(NO.2010-2015)

摘　　要：目的:评价降压宝系列中成药治疗原发性高血压的临床疗效与安全性。方法:检索Pub Med,万方数据库,维普网,中国期刊全文数据库(CNKI)中公开发表的降压宝治疗原发性高血压的临床随机对照试验,根据RCT质量评价Jadad量表评价标准对纳入文献进行质量评价,使用Revman5.2统计软件进行Meta分析。结果:Meta分析结果显示:降压宝系列中成药治疗原发性高血压与对照组相比在临床有效率上有明显的优势OR=5.53,%95CI=(2.21,13.85),整体效果检验Z=3.65(P=0.0003<0.05)。2研究中报道410例中出现42例不良反应,发生率为10%。结论:降压宝系列中成药治疗原发性高血压有较好疗效及安全性,但还需要高质量的随机对照试验增加其循证依据。Objective To systematically evaluate the efficacy of Jiang Ya Bao in the treatment of essential hypertension.Methods： According to strict inclusive and exclusive criteria,through electronic searches of relevant randomized controlled trials（RCTS） on Jiang Ya Bao for essential hypertension in Pub Med,Wan Fang Data, Wei Pu Data and CNKI. All reviewed literature were assessed Jadad quality scale.Data statistical analyses were performed by REVMan5.2 software. Results Meta-analysis showed that compared with the control group, Jiang Ya Bao significantly improved overall response rate, the total odd ratios（OR） were 5.53,95%confidence interval（CI） =（2.21,13.85）,between the two groups（Z=3.65, P=0.00030.05）. Two studies reported 42 cases of adverse reactions in 410 cases, The rate was 10%.Conclusion Jiang Ya Bao treatment for essential hypertension shows curative effect. However,But also need high-quality randomized controlled trials to increase its evidence-based.

关 键 词：原发性高血压 降压宝 随机对照试验 META分析 

分 类 号：R259.441[医药卫生—中西医结合]