某院58例儿童使用哌拉西林/他唑巴坦不良反应报告分析  

An Analysis of 58 ADR Induced by Piperacillin/Tazobactam Sodimn in A Hospital

作　　者：罗德凤[1] 祁兢晶[1] 邹振红 

机构地区：[1]深圳市妇幼保健院临床药学室,广东深圳518172

出　　处：《今日药学》2015年第6期461-464,共4页Pharmacy Today

摘　　要：目的了解哌拉西林/他唑巴坦注射液引起儿童药物不良反应（ADR）的规律和特点,为临床合理用药提供参考。方法对本院2012-01-2014-12收集的58例儿童使用哌拉西林/他唑巴坦注射液的ADR报告进行统计分析。结果 58例儿童使用哌拉西林/他唑巴坦ADR中,男孩ADR发生率（67.24%）明显高于女孩（32.76%）;其中新的一般、严重的ADR分别占总数的10.35%和1.72%。临床表现主要为皮疹、过敏反应等皮肤及附件表现,及时经抗休克、抗过敏处理后均可痊愈。结论儿童使用哌拉西林/他唑巴坦注射液时需更加关注临床合理用药,加强ADR的监测,特别是治疗周期较长的应定期监测血常规及肝肾功能,以免发生DRESS综合征等严重不良反应并及时停药。OBJECTIVE To investigate the rules and characteristics of ADR in children induced by piperacillin / tazobactam,and to provide reference for rational drug application in the clinic. METHODS A total of 58 ADR reports of piperacillin / tazobactam reported in the hospital from January 2012 to December 2014 were analyzed statistically. RESULTS In 58 cases of ADR reports,the proportion of boys（67. 24%） was significantly higher than girls（32. 76%）. 10. 35% of the ADR cases were new and 1. 72% of the ADR cases were serious. Main clinical manifestations were lesions of skin and its adnexa. Timely anti-allergic and anti-shock treatment was generally able to quickly relieve symptoms. CONCLUSION Clinicians should pay more attention to piperacillin / tazobactam use in children,strengthen ADR monitoring and dispose to reduce the occurrence of ADR and ensure the safety of medication use. Patients with long treatment cycle should be regularly monitored blood routine examination,hepatic function and renal function,so as to reduce the occurrence of serious ADR such as DRESS syndrome.

关 键 词：儿童 哌拉西林他唑巴坦 不良反应 DRESS综合征 

分 类 号：R97[医药卫生—药品]