整合素及其在眼科疾病中的作用  

The integrin and its role in eye diseases

作　　者：周桂贞[1] 张兴儒[1] 

机构地区：[1]上海中医药大学附属普陀医院眼科,200062

出　　处：《国际眼科纵览》2015年第3期206-209,共4页International Review of Ophthalmology

基　　金：上海市卫生局科研基金资助项目课题（20124415）

摘　　要：整合素是由细胞分泌,存在于细胞表面的一种跨膜蛋白.其主要功能是参与细胞与细胞、细胞与细胞外基质的黏附和信号转导.在晶状体的发育与晶状体疾病、青光眼、角膜病、近视、增生性玻璃体视网膜病变中,整合素参与细胞的识别、活化和信号转导,参与细胞的增生、分化以及细胞的伸展和迁移,从而改变了细胞与细胞外基质的微环境,引起一系列生理病理变化.Integrin is a transmembrane protein,which is secreted by the cell and expressed on the cell surface.The major function of integrinis is participating cell to cell and cell to extracellular matrix adhesion and signal transduction.Integrin is involved in the cell recognition,activation and signal transduction,cell proliferation and migration,differentiation and cell extend.These change the cells and the corresponding microenvironment of the extracellular matrix,and cause a series of physiological and pathological changes.Integrin is invovled in the physiological development of lens and pathological development of lens diseases,glaucoma,corneal disease,myopia and proliferative vitreous retinopathy.

关 键 词：整合素 信号转导 眼病 

分 类 号：R392.11[医药卫生—免疫学]