重复经颅磁刺激联合艾司西酞普兰治疗产后抑郁症的对照研究  

The association study of treating postpartum depression by repetitive transcrania! magnetic stimulation combined with Escitalopram

作　　者：孙红杰[1] 李学灵[1] 刘艳江[1] 芦新岩[1] 石岩[1] 陈会然[1] 

机构地区：[1]河北省荣军医院,河北保定071000

出　　处：《医学美学美容（中旬刊）》2015年第5期28-28,共1页

摘　　要：目的：探讨重复经颅磁刺激（rTMS）联合艾司西酞普兰治疗产后抑郁症的疗效及安全性。方法：将78侧产后抑郁症住院患者随机分为治疗组39例和对照组39例。两组均给予艾司西酞普兰10～20mg／d治疗，治疗组在此基础上应用重复经颅磁刺激治疗，疗程4周。在治疗前和治疗后1、2、4周末采用HAMD量表评定抑郁症状，采用TESS量表评定副反应。结果：共完成75例，研究组38例，对照组37例。两组HAMD评分在治疗2周及4周末-9治疗前比较差异均有统计学意义（P〈0．01），而治疗组HAMD评分在治疗1周末与治疗前比较差异即有统计学意义（P〈0．05）。两组均未观察到明显的副反应。结论：重复经颅磁刺激联合艾司西酞普兰治疗产后抑郁症疗效肯定，起效迅速，且不增加不良反应。Objective ： to investigate the efficacy and safety of repetitive transcranial magnetic stimulation （rTMS） combined with Escitalopram for postpartum depression. Methods ： 78 cases of hospitalized patients with postpartum depression were randomly divided into treatment group （39 cases） and control group （39 cases）. Two groups were given escitalopram 10 to 20 mg/ d for treatment, on the same time,the treatment group applied repetitive transcranial magnetic stimulation treatment, course of 4 weeks. Before and after treatment 1,2, 4 weekend, HAMD rating scale were used to evaluate depression symptoms, TESS rating scale were used to evaluate side effects. Results： 75 cases were completed the treatment, the treatment group 38 cases,the control group 37 cases. There were sianificantly different in HAMD scores between the treatment of the 2,4 weeked and before treatment in both two groups （ P 〈 0. 01 ）, and treatment group show sianificantly different in HAMD scores between the treatment of the 1 weekend and before treatment （ P 〈 0. 05 ）. The significant side effects were not observed in the two groups. Conclusion ： Repetitive transcranial magnetic stimulation combined with Escitalopram has more quickly and significant effect, and do not increase adverse reactions in the treatment of postpartum depression.

关 键 词：重复经颅磁刺激 产后抑郁症 艾司西酞普兰 

分 类 号：R722.12[医药卫生—儿科]