注射钆剂后弥散加权成像对乳腺肿瘤诊断的影响  

Evaluation of the diffusion-weighted imaging after contrast for the characterization of breast tumors

作　　者：黄娟[1] 颜剑豪[1] 梁联保[1] 江桂华[1] 

机构地区：[1]广东省第二人民医院影像科,广州510310

出　　处：《国际放射医学核医学杂志》2015年第4期287-291,共5页International Journal of Radiation Medicine and Nuclear Medicine

摘　　要：目的评估1．5 T MRI中乳腺肿瘤患者使用钆对比剂是否对弥散加权成像（DWI）有显著性影响。方法行乳腺MRI检查的女性患者40例（共计44个病灶），分别测量增强前后DWI图像信噪比（SNR）和对比噪声比（CNR）、病灶增强前后的表观扩散系数（ADC）及指数表观扩散系数（eADC）。结果给药前后DWI图像的SNR及CNR差异无统计学意义。乳腺癌给药前后的ADC值（t=4．023，P=0．001）及eADC值（t=4．082，P=0．001）差异有统计学意义，良性肿瘤给药前后的ADC值（t=1．700，P=0．103）及eADC值（t=1．341，P=0．194）差异无统计学意义。结论增强后行DWI是可行的，并且有助于提高其鉴别乳腺良恶性肿瘤的能力。Objective To evaluate the effects of intravenous gadolinium-DTPA on the diffusion- weighted imaging （DWI） of the breast. Methods A total of 40 women with 44 mass-like breast lesions were examined using 1.5-T MRI. The signal-to-noise ratios （SNRs） of the normal breast and the lesions, the contrast-to-noise ratios （CNRs）, apparent diffusion coefficient （ADC）, and exponent apparent diffusion coefficient （ eADC ） values of each lesion were measured from the DWI images before and after contrast enhancement. Results The SNRs and CNRs of the DWI images before and after contrast enhancement were not significantly different. In addition, no significant difference between the ADC and eADC values before and after contrast enhancement was observed in the benign lesions, whereas the opposite was observed in the malignant lesions. Conclusions The application of DWI after contrast enhancement is feasible in characterizing lesions in the breast. After contrast enhancement, the ADC values were significantly lower, and the eADC values were significantly higher in breast carcinomas. DWI after contrast media may improve the diagnosis of malignant breast lesions.

关 键 词：乳腺肿瘤 磁共振成像 弥散 钆DTPA 

分 类 号：R445.2[医药卫生—影像医学与核医学] R737.9[医药卫生—诊断学]