miRNAs在放射医学研究中的应用  

MicroRNAs and their applications in radiation medicine

作　　者：冉曦[1,4] 王明科[3] 冉新泽 王艾平[1] 

机构地区：[1]第三军医大学军事预防医学院全军复合伤研究所,重庆400038 [2]创伤、烧伤与复合伤国家重点实验室 [3]海军医学研究所,上海200433 [4]第三军医大学新桥医院检验科,重庆400037

出　　处：《国际放射医学核医学杂志》2015年第4期332-335,共4页International Journal of Radiation Medicine and Nuclear Medicine

基　　金：国家自然科学基金（81172600,81272101）

摘　　要：microRNAs（miRNAs）是一类内源性的非编码RNA，通过与靶mRNA特异性的结合而导致靶mRNA降解或抑制其翻译，对基因进行转录后调控，进而影响各种生命活动。大量研究表明，miRNAs与辐射致癌效应、辐射增敏效应、肿瘤辐射抗拒和辐射旁效应密切相关，已成为放射医学研究的热点。笔者就miRNAs及其在放射医学研究中的应用作一综述。MicroRNAs （miRNAs） are endogenous non-coding RNAs, which can degrade their target mRNAs or inhibit their translation by binding to their target mRNAs specifically. MiRNAs act as post-transcriptional regulators of gene expression, and then are involved in diverse physiological activities. Many studies has shown that miRNAs are closely related with radiation carcinogenesis, radiosensitivity, radioresistance and radiation-induced bystander effects, and have being a hotspot in radiation-medicine research. This review focuses on the introduction of miRNAs and their applications in radiation medicine.

关 键 词：微小RNAS 放射医学 辐射致癌 辐射增敏 辐射抗拒 

分 类 号：R815[医药卫生—放射医学]