Synthesis, Crystal Structure and Biological Properties of One Zinc(Ⅱ) Complex Based on 4-Acyl Pyrazolone Derivative  

作　　者：何川川 李玥 赵晶 许贯诚 孙素荣 

机构地区：[1]Key Laboratory of Material and Technology for Clean Energy,Ministry of Education,Key Laboratory of Advanced Functional Materials, Autonomous Region,Institute of Applied Chemistry,Xinjiang University [2]Xinjiang Key Laboratory of Biological Resources and Genetic Engineering,College of Life Science and Technology, Xinjiang University

出　　处：《Chinese Journal of Structural Chemistry》2015年第7期1019-1027,共9页结构化学（英文）

基　　金：Supported by the National Science Foundation of China(No.21161019,21301146);Natural Science Fund for Distinguished Young Scholars of Xinjiang Uygur Autonomous(No.2013711008);Technological Innovation Youth Training Project of Xinjiang Autonomous(No.2013721017)

摘　　要：[Zn（L）（CH3OH）3]（H2L = N-（1-phenyl-3-methyl-4-propenylidene-5-pyrazolone）-salicylidene hydrazide） has been synthesized by the reaction of zinc nitrate and ligand H2 L. The complex crystallizes in orthorhombic system, space group Pbca with a = 5.888（15）, b = 14.564（14）, c = 22.20（2） , V = 5137（8） 3, Z = 8 and F（000） = 2184. The ligand serves as a negative bivalent tridentate chelating agent to coordinate with the central zinc（II） atom. DNA-binding was studied by UV-Vis spectral analysis and ethidium bromide（EB） displacement experiments. The results showed that the DNA-binding constant of the complex is 5.1×104 M–1. Antitumor activity of [Zn（L）（CH3OH）3] and the ligand have been investigated by MTT assay, which indicated that the complex has better cytotoxicity to Eca-109 and He La than free ligand.[Zn（L）（CH3OH）3]（H2L = N-（1-phenyl-3-methyl-4-propenylidene-5-pyrazolone）-salicylidene hydrazide） has been synthesized by the reaction of zinc nitrate and ligand H2 L. The complex crystallizes in orthorhombic system, space group Pbca with a = 5.888（15）, b = 14.564（14）, c = 22.20（2） , V = 5137（8） 3, Z = 8 and F（000） = 2184. The ligand serves as a negative bivalent tridentate chelating agent to coordinate with the central zinc（II） atom. DNA-binding was studied by UV-Vis spectral analysis and ethidium bromide（EB） displacement experiments. The results showed that the DNA-binding constant of the complex is 5.1×104 M–1. Antitumor activity of [Zn（L）（CH3OH）3] and the ligand have been investigated by MTT assay, which indicated that the complex has better cytotoxicity to Eca-109 and He La than free ligand.

关 键 词：zinc（Ⅱ） complex 4-acyl pyrazolone derivative crystal structure DNA-binding antitumor activity 

分 类 号：O641.4[理学—物理化学]