β-防御素在感染和炎症过程中的作用  

The role of β- defensin in the process of infection and inflammation

作　　者：金鑫[1] 张曼[1] 范燕茹[1] 王佩[1] 杨银凤[1] 

机构地区：[1]内蒙古农业大学兽医学院,呼和浩特010018

出　　处：《黑龙江畜牧兽医》2015年第7期55-57,共3页Heilongjiang Animal Science And veterinary Medicine

基　　金：国家自然科学基金项目(31160491)

摘　　要：防御素(defensins)在整个进化过程中构成了动物体内最大的一组宿主防御肽,这些富含半胱氨酸的阳离子肽具有广谱的抗微生物活性,能有效杀灭细菌、酵母和病毒等微生物。因此,防御素是生物体内先天性免疫的一个主要组成部分。防御素在免疫调节中的功能已被广泛研究,文章综述了β-防御素的免疫调节活性及β-防御素在感染和炎症过程中作用的最新进展。Defensins constitute the largest group of host defence peptides in the body of animals during the entire course of evolution. These cysteine- rich cationic peptides have a broad spectrum antimicrobial activity,and can effectively kill bacteria,yeast,viruses,and other microorganisms. Therefore,defensins are a major component of innate immunity in the organisms. The functions of defensins in immunomodulation have been widely investigated. This article reviews the latest advances in the immunomodulatory activity of β- defensins as well as the role of β- defensins in the process of infection and inflammation.

关 键 词：Β-防御素 宿主防御肽 先天性免疫 免疫调节活性 感染 炎症 进展 

分 类 号：Q516[生物学—生物化学]