质子泵抑制剂的应用风险分析  

Risk Analysis of the Application of Proton Pump Inhibitors

作　　者：高明生[1] 陈拥军[1] 

机构地区：[1]四川省遂宁市中心医院消化内科,629000

出　　处：《中国全科医学》2015年第20期2448-2450,共3页Chinese General Practice

摘　　要：质子泵抑制剂(PPI)已成为世界范围内普遍使用的药物之一,广泛用于酸相关性疾病的治疗,如消化性溃疡、胃食管反流病、Zollinger-Ellison综合征等。本研究探讨了使用PPI的潜在风险,包括骨折、肺部感染、心血管事件、营养吸收障碍、胃肠道感染、胃结直肠癌等,并分析了其作用机制。Proton Pump Inhibitors（PPI） have become one of the most commonly used medications worldwide.They are widely used in the treatment for acid-related gastrointestinal disorders,such as peptic ulcer,gastroesophageal reflux disease（GERD）,Zollinger-Ellison syndrome,etc.However,concerns have been raised about PPI therapy,including the risk of bone fractures,pneumonia,cardiovascular events,absorb nutrition disorders,enteric infections and gastric and colorectal cancer.The mechanism of action was also analyzed.

关 键 词：质子泵抑制剂 骨折 肺部感染 氯吡格雷 营养不良 胃肠道 胃结直肠癌 妊娠 

分 类 号：R977.3[医药卫生—药品]