脓毒症合并肾上腺功能不全/相对肾上腺功能不全的糖皮质激素治疗进展  

Progress in the Treatment of Sepsis Complicated With Adrenal Insufficiency or Relative Adrenal Insufficiency by Glucocorticoids

作　　者：林霖[1,2] 周荣斌[1] 

机构地区：[1]中国人民解放军北京军区总医院急诊科,北京市100000 [2]安徽医科大学研究生学院

出　　处：《中国全科医学》2015年第21期2594-2598,共5页Chinese General Practice

基　　金：首都医学发展基金联合攻关课题(2009-1026)

摘　　要：近年来脓毒症患者常见的并发症是肾上腺功能不全(AI),同时也可能出现相对肾上腺功能不全(RAI),导致其体内血浆皮质醇水平降低,造成高病死率。但近年的研究中,关于脓毒症合并AI/RAI尚缺乏深层的认识,而且目前尚无统一的诊断标准。本文介绍了脓毒症合并AI/RAI的流行病学、发病机制、诊断标准及治疗干预,表明糖皮质激素可以通过升高脓毒症合并AI/RAI患者的血浆皮质醇水平,改善预后。Adrenal insufficiency is a common complication in patients with sepsis in recent years of Beijing PLA, andrelative adrenal insufficiency may also occur. It may lead to the reduction of plasma cortisol level and high mortality in patients. But in the researches of recent years, there is a lack of deeper understanding about adrenal insufficiency, and there is no unified diagnogtic criterion. This paper introduced the epidemiology, pathogenesis, main diagnostic criteria and treatment intervention of sepsis complicated with adrenal insufficiency. It was indicated that glucocorticoids could improve prognosis by raising the plasma cortisol level in patients with sepsis complicated with AI/RAI.

关 键 词：脓毒症 肾上腺功能不全 糖皮质激素类 

分 类 号：R586[医药卫生—内分泌]