盐酸氮卓斯汀与布地奈德治疗持续性变应性鼻炎的临床疗效评价  

Clinical effect of azelastine and budesonide nasal sprays in adult patients with persistent allergic rhinitis

作　　者：尹倩[1] 陈晓云[1] 陈建福[1] 廖志苏[1] 

机构地区：[1]温州医科大学附属第一医院耳鼻喉科,浙江温州325000

出　　处：《中国临床药理学杂志》2015年第14期1369-1372,共4页The Chinese Journal of Clinical Pharmacology

摘　　要：目的评价盐酸氮卓斯汀鼻喷剂和布地奈德鼻喷剂对成人持续性变应性鼻炎(AR)生活质量的影响。方法将148例持续性鼻炎患者随机分为试验组50例、对照组50例和安慰剂组48例。试验组予以盐酸氮卓斯汀喷鼻,每日早、晚各1次,每次每侧鼻腔1喷,每喷0.14 mg;对照组予以布地奈德喷鼻,每日早上1次,每次每侧鼻腔2喷,每喷64μg;安慰剂组予以0.9%氯化钠喷鼻,每日早上1次,每次每侧鼻腔2喷,3组患者均持续用药4周。用鼻部症状评分、生活质量评价量表(SF-36)和鼻结膜炎相关生活质量问卷(RQLQ)比较3组患者鼻部症状改善和生活质量。结果最终共有133例持续性鼻炎患者入组,其中试验组46例、对照组45例、安慰剂组42例。试验组和对照组治疗后,第2,4周的鼻部症状评分、SF-36和RQLQ评分均较安慰剂组明显改善(P<0.05)。治疗4周后,对照组鼻部症状评分、SF-36和RQLQ评分改善均较试验组更为显著(P<0.05)。结论盐酸氮卓斯汀鼻喷剂和布地奈德鼻喷剂均能明显改善成人持续性鼻炎患者生活质量,但布地奈德鼻喷剂治疗4周对持续性鼻炎患者生活质量改善较盐酸氮卓斯汀鼻喷剂更显著。Objective To evaluate the clinical effect of azelastine hydrochloride and budesonide nasal spray in the quality of life（ QOL） in adult patients with persistent allergic rhinitis（ AR）. Methods One hundred fourty-eight patients with persistent AR were randomly divided into treatment group（ n = 50）,control group（ n = 50） and placebo group（ n = 48）. Treatment group was treated with azelastine hydrochloride nasal spray,one spray for each side of the nasal cavity in each morning and night,per spray was 0. 14 mg. Control group was treated with budesonide nasal spray,two sprays for each side of the nasal cavity in each morning,per spray was 64 μg. Placebo group was treated with 0. 9%Na Cl,two sprays for each side of the nasal cavity in each morning. Three groups were continued medication for 4 weeks. Comparison of nasal symptoms and quality of life in three groups by nasal symptom score,the MOS item from health survey（ SF-36） and rhinoconjunctivitis related quality of life questionnaire（ RQLQ）. Results In the azelastine hydrochloride and budesonide groups,after 4-week＇ s treatment,nasal symptom scores,SF-36 scores and RQLQ scores were significantlyimproved in comparison with the placebo group（ P〈0. 05）. Budesonide treatment for 4 weeks resulted in a significant improvement in nasal symptom scores,SF-36 scores and RQLQ scores than azelastine hydrochloride（ P〈0. 05）.Conclusion Our findings suggested that both azelastine hydrochloride and budesonide nasal spray can significantly improve quality of life in the treatment of adult patients with persistent AR. Moreover,this comparative provided the evidence that budesonide nasal spray is superior to azelastine hydrochloride nasal spray in improving quality of life of persistent AR patients.

关 键 词：鼻炎 变应性 盐酸氮卓斯汀 布地奈德 生活质量 

分 类 号：R765.21[医药卫生—耳鼻咽喉科]