谷氨酸在晕动病发病机制中的作用及相关药物研究  

Influence of glutamate on the pathogenesis of motion sickness and relative drugs research

作　　者：吕达娜[1] 林淑瑜[1] 黄阳[1] 杨昌云[1] 

机构地区：[1]解放军第180医院药学科,福建泉州362000

出　　处：《中国临床药理学杂志》2015年第14期1462-1465,共4页The Chinese Journal of Clinical Pharmacology

基　　金：南京军区医药卫生科研基金资助项目(12MA075)

摘　　要：谷氨酸不仅是人和哺乳动物中枢神经系统的基本兴奋性神经递质,也参与外周感觉系统的突触传递。然而,过量谷氨酸引起的谷氨酸受体过度激活导致谷氨酸兴奋性神经毒性。本文对谷氨酸在前庭终器的神经传递和谷氨酸在晕动病中对其的兴奋毒性进行了讨论,并对与谷氨酸神经传递过程相关的抗晕动病药物进行综述。Glutamate is not only the major excitatory neurotransmitter in the central nervous system of human and mammalian animals but also participates the synaptic transmission of peripheral sensory system. However,overstimulation of glutamate receptors by excessive glutamate leads to glutamate excitotoxicity. This review discusses the neurotransmission of glutamate in the vestibular end organs and the excitotoxicity by glutamate on them in motion sickness as well as the antimotion sickness drugs associated with glutamate neurotransmission.

关 键 词：谷氨酸 晕动病 兴奋性神经毒性 离子通道拮抗剂 谷氨酸受体拮抗剂 

分 类 号：R971[医药卫生—药品]