复方黄柏液治疗头皮银屑病的疗效观察  

Clinical Observation of Fufang Huangbai Liquid in Treating Scalp Psoriasis

作　　者：沈凤 肖晓庆[2] 程琼[2] 樊春燕[2] 左付国[2] 

机构地区：[1]上海市奉贤区中心医院,上海201400 [2]同济大学附属东方医院,上海200120

出　　处：《中国中西医结合皮肤性病学杂志》2015年第3期159-160,共2页Chinese Journal of Dermatovenereology of Integrated Traditional and Western Medicine

基　　金：汉方中医药皮肤病学研究基金(201308)

摘　　要：目的观察复方黄柏液治疗头皮银屑病的临床疗效。方法 150例患者随机分为治疗组、哈西奈德组和空白对照组,每组各50例,其中治疗组在皮损区外涂复方黄柏液,2次/d,4周为1个疗程,连续2个疗程;哈西奈德组外涂0.025%哈西奈德溶液,1次/d,疗程同治疗组;空白对照组不予外涂药物。在治疗前和治疗4周、8周时对头皮银屑病进行严重程度(PSI)评分和疗效评估。结果在治疗4周、8周时,治疗组PSI评分均明显低于空白对照组,差异有统计学意义;在治疗8周时,治疗组评分与哈西奈德组比较差异无统计学意义。在治疗8周时,治疗组和空白对照组的有效率分别为82.98%和56.52%,2组比较差异有统计学意义(χ2=7.73,P<0.01);但治疗组与哈西奈德组(89.80%)比较差异无统计学意义(χ2=0.95,P>0.05)。结论复方黄柏液治疗头皮银屑病安全、有效,值得临床推广应用。Objective To observe the efficacy of Fufang Huangbai liquid on treating scalp psoriasis. Methods 150 patients with scalp psoriasis were randomly divided into three groups： 50 patients in treatment group were received topical Fufanghuangbai liquid twice daily for eight weeks. 50 patients in the Halcinonide control group were received Halcinonide liquid topically once every morning for eight weeks and others were taken as blank control group. The psoriasis severity index（PSI） and efficacy were assessed before treatment,at the fourth and eighth week during treatment. Results PSI scores in treatment group were much lower than that in the blank control group at the fourth and eighth week during treatment. The effective rate in the treatment group and blank control group was 82.98% and 56.52% respectively,with significant difference. There was no significant difference between the treatment group and the Halcinonide control group with 89.80% of the effective rate.Conclusion Fufang Huangbai liquid is effective, safe and worthy of popularization and application in the treatment of scalp psoriasis.

关 键 词：头皮银屑病 复方黄柏液 哈西奈德溶液 

分 类 号：R758.63[医药卫生—皮肤病学与性病学]