胎儿纤维连接蛋白及宫颈长度对自发性早产的预测价值  

Predictive Values of Fetal Fibronectin and Cervical Length in Spontaneous Preterm Birth

作　　者：黄晓玲[1] 

机构地区：[1]中山市博爱医院产科,广东中山528403

出　　处：《实用临床医学（江西）》2015年第7期53-55,共3页Practical Clinical Medicine

摘　　要：目的探讨胎儿纤维连接蛋白（fFN）及宫颈长度（CL）变化对既往有早产史的孕妇进行早产预测的价值.方法对50例既往有早产史的单胎妊娠孕妇的宫颈分泌物fFN 进行免疫检测,腹部超声检查测量CL,观察fFN＋和fFN-、CL≤25mm 和〉25mm 孕妇35周前发生自发性早产的情况.结果50例孕妇中35周前发生自发性早产23例（46.0%,23/50）.fFN＋孕妇（n=27）早产发生率显著高于fFN-孕妇（n=23）（P〈0.001）,fFN＋ 与孕妇发生早产的风险有很高的关联[相对危险度（OR）为19.05,95%CI为4.30～84.33,P〈0.05].CL≤25mm 孕妇（n=29）早产发生率显著高于CL〉25mm 孕妇（n=21）（P〈0.001）,CL≤25mm 孕妇再次发生早产的风险很大（OR为8.08,95%CI为2.13～30.58,P〈0.05）.CL≤25 mm 组中fFN＋ 孕妇早产发生率显著高于fFN- 孕妇（P〈0.001）;而CL〉25mm 组中fFN＋和fFN-孕妇早产发生率比较差异无统计学意义（P〉0.05）.结论fFN 结合CL 测定对曾有自发性早产史的孕妇有一定的早产预测价值.Objective To explore the values of fetal fibronectin (fFN)and cervical length (CL) in the prediction of preterm birth in pregnant women with a history of spontaneous preterm birth. Methods The fFN in cervical secretions was detected by immunoassay and the CL was measured by abdominal ultrasonography in 50 singleton pregnant women with a history of spontaneous pre-term birth.The incidence of spontaneous preterm birth was observed in pregnant women with fFN+ (n=27),fFN- (n=23),CL≤25 mm (n=29)or CL>25 mm (n=21)before 35 weeks. Results Among the 50 pregnant women,spontaneous preterm birth occurred in 23 (46.0%)be-fore 35 weeks.The incidence of preterm birth in fFN+ pregnant women was significantly higher than that in fFN- pregnant women (P <0.001).The fFN+ was closely correlated with preterm birth (OR,19.05;95%CI ,4.30-84.33,P < 0.05).The incidence of preterm birth in pregnant women with CL≤25 mm is significantly higher than that in pregnant women with CL>25 mm (P <0.001).The risk for recurrence of preterm birth was high in pregnant women with CL≤25 mm (OR,8.08;95%CI ,2.13-30.58,P <0.05).Among pregnant women with CL≤25 mm,the incidence of preterm birth in fFN+ women was significantly higher than that in fFN- women (P <0.001).Among pregnant women with CL>25 mm,no significant difference in the incidence of preterm birth was found between fFN+ women and fFN- women(P >0.05).Conclusion The combined fFN and CL detection has predictive value for preterm birth in pregnant women with a history of spontaneous preterm birth.

关 键 词：孕妇 早产史 胎儿纤维连接蛋白 宫颈长度 早产预测 

分 类 号：R714.21[医药卫生—妇产科学]