不同的红细胞制品输注治疗儿童重型地中海贫血的不良反应  

Adverse Reactions of Infusion of Different Types of Red Cell Products in Children with Severe Thalassemia

作　　者：叶龙英 胡彩汀 

机构地区：[1]广州市荔湾区第三人民医院检验科,广州510000 [2]广州市荔湾区人民医院检验科,广州510000

出　　处：《实用临床医学（江西）》2015年第7期64-66,共3页Practical Clinical Medicine

基　　金：广州市卫生局医药卫生科技项目(20131A011179)

摘　　要：目的探讨不同的红细胞制品输注治疗儿童重型地中海贫血的不良反应。方法将68例重型地中海贫血患儿按治疗方法的不同分为A组、B组、C组和D组,每组17例。A组输注普通红细胞,B组输注洗涤红细胞,C组输注年轻红细胞,D组输注去白红细胞。比较4组不良反应[非溶血性发热性输血反应(FNHTR)和免疫介导的输血不良反应、输血传播的感染及输血性铁过载]发生率。结果 4组均未发生输血传播的感染。C、D 2组FNHTR和免疫介导的输血不良反应、输血性铁过载发生率均明显低于A、B 2组(均P<0.05)。结论年轻红细胞输注和去白红细胞输注治疗儿童重型地中海贫血能够降低感染及不良反应的发生率,对去铁治疗有促进作用,值得临床上进一步推荐和应用。Objective To investigate the adverse reactions of infusion of different types of red cell products in children with severe thalassemia.Methods A total of 68 children with severe thalassemia were treated with the infusion of normal red blood cells(group A,n=17),washed red blood cells(group B,n=17),young red blood cells(group C,n=17)or leukocyte-poor red blood cells(group D,n=17).The incidences of febrile non-hemolytic transfusion reactions(FNHTR), immune-mediated adverse reactions,transfusion-transmitted infections and transfusion iron over-load were compared among the four groups.Results No patients had transfusion-transmitted in-fections in all the four groups.The incidences of FNHTR,immune-mediated adverse reactions and transfusion iron overload in group C and D were significantly lower than those in group A and B (P <0.05).Conclusion The transfusion of young red blood cells or leukocyte-poor red blood cells which can reduce the incidences of infections and complications in children with severe thalassemia and improve the efficacy of iron treatment.Therefore,it is worthy of further recom-mendation and application.

关 键 词：重型地中海贫血 输血 红细胞 不良反应 儿童 

分 类 号：R725.5[医药卫生—儿科]