磷酸肌酸在围生期的应用  

Application of Creatine Phosphate in Perinatal Period

作　　者：吕丽贤[1] 张陈彦[1] 安雪丽 张铭娜[1] 张立新[1] 

机构地区：[1]石家庄市第一医院产科,石家庄050011

出　　处：《医学综述》2015年第13期2327-2329,共3页Medical Recapitulate

基　　金：石家庄市科技计划指导项目(141462453)

摘　　要：磷酸肌酸广泛应用于各科临床,而且新的药理作用不断被发现。近年来磷酸肌酸在围生期的应用研究发现,磷酸肌酸在孕期可改善胎儿宫内缺氧状态,在胎儿生长发育中保护神经系统,补充外源性的磷酸肌酸可使心力衰竭孕妇心肌收缩力增加,从而改善其心脏功能。另外,磷酸肌酸可有效预防新生儿出生后低血糖、治疗发生窒息新生儿的心肌损伤,提示磷酸肌酸对维护母婴健康方面有重要的临床作用,在产科有广阔的应用前景,同时也为临床合理用药提供了依据。Creatine phosphate is widely applied in clinical,and the new pharmacological activities have been found：creatine can improve fetal hypoxia during pregnancy, and protect the nervous system on fetal growth and development.The heart failure of pregnant women supplementation creatine during pregnancy can cause increased myocardial contraction force to improve the heart function .In addition,creatine can effectively prevent the occurrence of hypoglycemia,treat myocardial damage following neonatal asphyxia,which suggests creatine phosphate has an important clinical role in maintaining the maternal and infant health ,and has broad application prospects in obstetrics,providing the basis for rational clinical drug use as well.

关 键 词：磷酸肌酸 围生期 胎儿窘迫 胎儿神经系统 妊娠合并心力衰竭 

分 类 号：R99[医药卫生—毒理学]