亲环素A与慢性心力衰竭关系的研究进展  

Research Progress in the Relationship between Cyclophilin A and Chronic Heart Failure

作　　者：周丽平[1] 吴士礼[1] 包宗明[1] 

机构地区：[1]蚌埠医学院第一附属医院心内科,安徽蚌埠233000

出　　处：《医学综述》2015年第13期2385-2387,共3页Medical Recapitulate

摘　　要：在全球范围内,心力衰竭仍然是一个常见的、致残的、致死性的疾病。随着人口老龄化的增加和早期患高血压、缺血性心肌病等心血管疾病人口的存活,心力衰竭负担逐渐加重,与此同时心力衰竭的早期诊治如在无症状综合征期改善血流动力学的研究报道也不断增多。最新研究表明,亲环素A通过CD147分子、血管紧张素Ⅱ等在心血管重构中发挥重要作用,其有可能成为心力衰竭研究的新靶点。Heart failure is still a common, disabling and deadly disease all over the world.With the increase of aged population and the survival of population with early cardiovascular disease such as hyperten-sion,ischemic cardiomyopathy,the burden of heart failure is being heavier.The studies of active prevention and treatment of heart failure like improving hemodynamics in patients without symptoms are also increasing at the same time.The latest reports show that Cyclophilin A through CD147 molecules,angiotensin Ⅱ plays an important role in the cardiovascular remodeling .Cyclophilin A is likely to become a new target in the study of heart failure.

关 键 词：慢性心力衰竭 亲环素A CD147分子 血管紧张素Ⅱ 

分 类 号：R541.6[医药卫生—心血管疾病]