钯催化多组分反应合成喹啉化合物研究  

Synthesis Quinoline Compounds by Palladium Catalyzed Multicomponent Reaction

作　　者：罗君[1] 卢平平[1] 方宇[1] 朱育林[1] 曾卓[1] 

机构地区：[1]华南师范大学化学与环境学院,广州510006

出　　处：《华南师范大学学报（自然科学版）》2015年第4期61-68,共8页Journal of South China Normal University(Natural Science Edition)

基　　金：国家自然科学基金项目(21272080)

摘　　要：以芳香醛、芳香胺和二氢呋喃或二氢吡喃为原料,在氯化钯和苄基三乙基氯化铵的复合催化作用下,在乙腈溶剂中进行多组分反应,高收率地合成了一系列的苯并呋喃类喹啉类衍生物和苯并吡喃类喹啉类衍生物,所有产物均通过熔点、IR、1H NMR、13C NMR、MS和单晶测试等手段进行结构鉴定与表征,其中包括12个新化合物.探讨了上述多组分反应的最佳反应温度、最佳催化剂及用量,并推测了可能的反应机理.A serials of dihydro-furoquinoline derivatives or dihydro-pyranquinoline derivatives have been synthesized, catalyzed by palladium chloride/benzyl triethyl ammonium chloride （BTEAC） in the multicomponent reaction of aromatic aldehydes, aromatic amines and 2,3-dihydrofuran or 3,4-dihydropyran in acetonitrile. All the generated products have been identified and characterized by means of melting point, IR, ^1H NMR, ^13C NMR, MS and X-ray diffraction analyses. Among them, 12 compounds haven＇t been reported formerly. The reaction temperature, catalyst and catalyst contents have been studied. A possible mechanism for the present catalytic reaction was proposed.

关 键 词：氯化钯 苄基三乙基氯化铵 苯并呋喃类喹啉类衍生物 苯并吡喃类喹啉类衍生物 多组分反应 

分 类 号：O626.323[理学—有机化学]