OSAHS患者血清MIF水平的变化及意义  

Changes and Significance of Serum MIF Levels in OSAHS of Patients

作　　者：张淑文[1] 赵国锋[2] 许玉静[2] 李明[1] 刘亚辉[3] 李林旭[1] 张蕊[3] 王红阳[4] 

机构地区：[1]河北省唐山市协和医院呼吸科,063000 [2]河北省唐山市协和医院耳鼻喉科,063000 [3]河北省唐山市协和医院检验科,063000 [4]河北联合大学附属医院呼吸科,唐山063000

出　　处：《医学研究杂志》2015年第8期159-161,共3页Journal of Medical Research

摘　　要：目的探讨阻塞型睡眠呼吸暂停低通气综合征(OSAHS)患者血清MIF浓度变化及与糖代谢的关系,进一步探讨OSAHS患者发病机制。方法选择经多导睡眠监测(PSG)确诊的OSAHS患者[睡眠呼吸暂停低通气指数(AHI≥5次/小时)]66例作为病例组,25例单纯打鼾患者(AHI<5次/小时)作为对照组,测定并比较上述两组的血清MIF及糖代谢指标的差异,并分析OSAHS患者血清MIF及糖代谢各指标的相关性。结果 1OSAHS患者的血清MIF浓度水平高于正常对照组,差异有统计学意义;2OSAHS患者的FPG、FINS、MIF与AHI呈正相关(r分别为0.508、0.411、0.449,P<0.01),与LSp O2呈负相关(r分别为-0.380、-0.287、-0.405,P<0.01)。OSAHS患者的ISI与AHI呈负相关(r=-0.493),与LSp O2呈正相关(r=0.486)。OSAHS患者的FPG与MIF呈正相关(r=0.255,P<0.05),MIF与BMI无关(r=0.198,P>0.05)。结论 OSAHS患者存在炎性反应,并且存在糖代谢紊乱,血清MIF可能参与了OSAHS患者糖代谢紊乱。Objective To explore the association of serum MIF and carbohydrate metabolism in patients with OSAHS,and to investi- gate the pathogenesis of OSAHS. Methods Patients were divided into two groups, 66 cases of patients with OSAHS diagnosed by poly- somnography （PSG） （AHI≥ 5 times/h） as the patient group, 25 cases of simple snoring patients （AHI 〈 5 times/h） as the control group. Determine and compare the differences between serum MIF and the indicators of carbohydrate metabolism in the two groups, and analyze the correlation between serum MIF and the indicators of carbohydrate metabolism. Results Compared with the levels of MIF be- tween OSAHS group and the control group, the OSAHS group was higher than the control group, the difference was statistically significant （P 〈0.05）. FPG, FINS, MIF in OSAHS group have positive correlation with AHI（r =0.508, 0.411, 0.449, P 〈0.01） , and nega- tive correlation with LSpO2 （ r = - 0. 380, - 0. 287, - 0. 405, P 〈 0.01 ）. ISI has negative correlation with AHI in OSAHS group （ r = -0. 493） , and positive correlation with AHI（ r = 0. 486）. MIF has positive correlation with FPG in OSAHS group, and is unrelated with BMI. Conclusion There is inflammation and abnomal carbohydrate metabolism in patients with OSAHS. Serum MIF may be involved in abnomal carbohydrate metabolism.

关 键 词：OSAHS MIF 代谢紊乱 

分 类 号：R562.1[医药卫生—呼吸系统]