基于中空介孔二氧化硅小球的pH响应性控制释放系统  

pH-Response controlled release system based on hollow mesoporous silica nanoparticles

作　　者：桂万元 王文谦 焦翔宇[1,2] 陈林峰 温永强[1,2] 宋延林 张学记[1,2] 

机构地区：[1]生物工程与传感技术研究中心 [2]北京科技大学化学与生物工程学院,北京100083 [3]中国科学院化学研究所新材料实验室,北京100190

出　　处：《中国科学：化学》2015年第7期703-709,共7页SCIENTIA SINICA Chimica

基　　金：国家自然科学基金(21171019;21073203);教育部新世纪优秀人才支持计划(NCET-11-0584);中央高校基本科研业务费专项资金资助

摘　　要：空心结构的介孔二氧化硅纳米材料具有较大的比表面积和孔容积,相对于传统介孔氧化硅材料可以负载更多的药物分子,在药物缓释领域具有广阔的应用前景.本文利用改进的模板法制备了粒径与壳厚度可控的中空介孔二氧化硅纳米小球.采用透射电镜(TEM)、小角X射线散射分析(SAXS)和氮气吸附-脱附等方法对合成的中空纳米二氧化硅小球进行了表征分析,得出最佳制备工艺条件.选择优化的制备条件得到的中空介孔二氧化硅与普通介孔二氧化硅对比,将两者分别负载一定量的染料分子罗丹明B(RhB),接着在两者表面修饰溶菌酶分子作为开关分子,构筑了两个pH响应的药物控制释放系统,并对两者的装载量进行了评估,通过观察在575 nm(RhB)处荧光发射峰强度的变化来评估两者的控制释放效果在相同的时间内,空心结构的介孔二氧化硅小球释放染料分子的量要明显多于普通介孔二氧化硅小球释放染料分子的量.Compared with the conventional mesoporous silica materials, hollow structured mesoporous silica materials can loaded more drug molecules due to the large surface area and the total pore volume, which have an extensive application prospect in the field of drug controlled release. In this paper, the hollow structured mesoporous silica nanoparticles with controllable particle size and shell thickness was successfully synthesized by a modified template method. The hollow structured mesoporous silica nanoparticles were characterized by transmission electron microscopy（TEM）, small angle X-ray scattering analysis（SAXS）, nitrogen adsorption-desorption analysis, and the optimum preparation conditions was obtained. Furthermore, it had a comparative study to evaluate the effects of the obtained hollow mesoporous silica and ordinary mesoporous silica on the ability of drug release. The two samples loaded a certain amount of dye molecules of rhodamine B（RhB）, and then the modification lysozyme molecules in the surface designed as a molecular switch. The two p H-response controlled release system was constructed in order to evaluate the corresponding loading contents. The drug release rate was investigated by monitoring the changed of fluorescence intensity at 575 nm（Rh B）. During the same period, more dye molecules released from the hollow structured mesoporous silica materials than the conventional mesoporous silica materials.

关 键 词：介孔材料 中空结构 药物释放 传感器 

分 类 号：TQ127.2[化学工程—无机化工] TQ460.1