妊娠期中重度OSAHS患者血凝参数变化及临床意义  

Coagulation parameter transmutations and clinical significances for pregnancy with moderate to severe OSAHS patients

作　　者：毕秀敏[1] 王坤[1] 张彩英[1] 

机构地区：[1]山东荣成市人民医院耳鼻咽喉科,264300

出　　处：《中国中西医结合耳鼻咽喉科杂志》2015年第3期169-171,共3页Chinese Journal of Otorhinolaryngology in Integrative Medicine

摘　　要：目的探讨妊娠合并OSAHS患者凝血参数的变化及临床意义。方法应用sysmex全自动血凝仪对正常妊娠组、妊娠合并OSAHS组妇女凝血酶原时间(PT)、活化部分凝血酶时间(APTT)、血浆纤维蛋白原(FIB)、D-二聚体(D-D)检测,同时妊娠合并OSAHS组妇女分轻、中、重组,对其也进行以上四项指标的监测。结果妊娠合并OSAHS组较正常妊娠组PT、APTT明显缩短(P<0.01),FIB、D-D增高(P<0.01),差异有统计学意义;妊娠合并中重度OSAHS患者较妊娠合并轻度OSAHS患者PT、APTT明显缩短(P<0.05),FIB、D-D增高(P<0.05),差异有统计学意义。结论妊娠合并中重度OSAHS者的血液呈现高凝状态,应给予充分干预,以尽量降低相关不良反应的发生。Objective Objective pregnancy complicated with obstructive sleep apnea hypopneasyndrome （OSAHS） hangesand clinical significance of coagulation parameters in patients with. Methods Application of Sysmex automatic blood coagulation analyzer in normal pregnancy group, OSAHS group of women with pregnancy prothrombin time （PT）, activated partial thromboplastin time （APTT）, plasma fibrinogen（FIB）, two D-dimer （D-D） detection, combined with OSAHS group of women in pregnancy and at the same time, light, reorganization, monitoring for the above four items on it. Results Pregnancy associated with OSAHS group than in normal pregnancy group PT, APTT decreased significantly （P〈0.01）, FIB, D-D increased（P〈0.01）, the difference was statistically significant;Pregnancy associated with moderate to severe OSAHS patients than in pregnancy complicated with mild OSAHS patients PT, APTT was shortened （P〈0.05）, FIB, D-D increased （P〈0.05）, the difference was statistically significant. Conclusion Pregnancy associated with moderate to severe OSAHS blood hypercoagulability, should give full intervention, to minimize the occurrence of adverse reactions.

关 键 词：阻塞性睡眠呼吸暂停低通气综合征 妊娠 血凝四项 

分 类 号：R714.25[医药卫生—妇产科学] R766[医药卫生—临床医学]